6-(Propan-2-yl)-3-methyl-morpholine-2,5-dione, a novel cyclodidepsipeptide with modulatory effect on rat thymocytes

被引：6
|
作者：
Pavlovic, Voja [1 ]
Cherneva, Emiliya [2 ]
Yancheva, Denitsa [3 ]
Smelcerovic, Andrija [4 ]
机构：
[1] Univ Nis, Fac Med, Inst Physiol, Nish 18000, Serbia
[2] Med Univ Sofia, Fac Pharm, Dept Chem, Sofia 1000, Bulgaria
[3] Bulgarian Acad Sci, Ctr Phytochem, Inst Organ Chem, BU-1113 Sofia, Bulgaria
[4] Univ Nis, Fac Med, Dept Chem, Nish 18000, Serbia
来源：
FOOD AND CHEMICAL TOXICOLOGY | 2012年 / 50卷 / 09期
关键词：
6-(Propan-2-yl)-3-methyl-morpholine-2,5-dione; Cyclodidepsipeptides; Thymocytes cytotoxicity; Oxidative stress; Mitochondrial membrane potential; CHIRAL 1,4-MORPHOLIN-2,5-DIONE DERIVATIVES; ALPHA-GLUCOSIDASE INHIBITORS; OXIDATIVE STRESS; ANTIMICROBIAL ACTIVITY; SANGLIFEHRIN-A; APOPTOSIS; CELLS; CYCLODEPSIPEPTIDES; PROLIFERATION; BINDING;
D O I：
10.1016/j.fct.2012.06.004
中图分类号：
TS2 [食品工业];
学科分类号：
0832 ;
摘要：
A study has been carried out on the potential effect of a novel cyclodidepsipeptide, 6-(propan-2-yl)-3-methyl-morpholine-2,5-dione (PMMD), on rat thymocytes. Rat thymocytes were cultivated with increasing PMMD concentrations (0.1, 1, 10 mu g/well), for 24 h, and evaluated for proliferative activity, viability, reactive oxygen species and mitochondrial membrane potential. The higher PMMD concentrations inhibited thymocytes proliferative activity mainly through induction of oxidative stress and resulting cytotoxicity, without any mitochondrial membrane potential alterations in thymocytes. The obtained results are correlated with previously published data on effects of 6-(propan-2-yl)-4-methyl-morpholine-2,5-diones on rat thymocytes. The presence of methyl group in position 4 or/and the length of alkyl chain in position 3 of 6-(propan-2-yl)-morpholine-2,5-dione core plays a role for the obtained differences in the biological response between PMMD and two previously tested 6-(propan-2-yl)-4-methyl-morpholine-2,5-diones. (C) 2012 Elsevier Ltd. All rights reserved.
引用
收藏
页码：3014 / 3018
页数：5
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