Dialysis dose in acute kidney injury: no time for therapeutic nihilism - a critical appraisal of the Acute Renal Failure Trial Network study

被引：24

作者：

Ronco, Claudio ^{[1
,2
]}

Cruz, Dinna ^{[1
,2
]}

van Straaten, Helen Oudemans ^{[3
]}

Honore, Patrick ^{[4
]}

House, Andrew ^{[5
]}

Bin, Du ^{[6
]}

Gibney, Noel ^{[7
]}

机构：

[1] St Bortolo Hosp, Dept Nephrol, I-36100 Vicenza, Italy

[2] Int Renal Res Inst Vicenza IRRIV, I-36100 Vicenza, Italy

[3] Onze Lieve Vrouw Hosp, Dept Intens Care, NL-1091 AC Amsterdam, Netherlands

[4] St Pierre Para Univ Hosp, Intens Care Unit, B-1340 Ottignies, Belgium

[5] London Hlth Sci Ctr, London, ON N6A 5A5, Canada

[6] Peking Union Med Coll, Med Intens Care Unit, Beijing 100730, Peoples R China

[7] Univ Alberta, Div Crit Care Med, Edmonton, AB T6G 2B7, Canada

来源：

CRITICAL CARE | 2008年 / 12卷 / 05期

关键词：

D O I：

10.1186/cc7016

中图分类号：

R4 [临床医学];

学科分类号：

1002 ; 100602 ;

摘要：

The optimal dialysis dose for acute kidney injury is a matter of great controversy. Clinical trials, predominantly single-center studies, have shown conflicting results. The Acute Renal Failure Trial Network (ATN) Study was designed to compare clinical outcomes between patients allocated to an intensive dose versus a less-intensive dose of renal replacement therapy. Recently, the results of this large randomized controlled multicenter study were published. The present article will discuss certain aspects of this trial: the overall design, the baseline patient characteristics, and comparison of the results with earlier studies. Finally, the article will address the implications of the ATN Study results for clinical practice.

引用

页数：7

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