ESCMID* guideline for the diagnosis and management of Candida diseases 2012: prevention and management of invasive infections in neonates and children caused by Candida spp.

被引：255

作者：

Hope, W. W. ^{[1
]}

Castagnola, E. ^{[2
]}

Groll, A. H. ^{[3
]}

Roilides, E. ^{[4
]}

Akova, M. ^{[5
]}

Arendrup, M. C. ^{[6
]}

Arikan-Akdagli, S. ^{[7
]}

Bassetti, M. ^{[8
]}

Bille, J. ^{[9
]}

Cornely, O. A. ^{[10
]}

Cuenca-Estrella, M. ^{[11
]}

Donnelly, J. P. ^{[12
]}

Garbino, J. ^{[13
]}

Herbrecht, R. ^{[14
]}

Jensen, H. E. ^{[15
]}

Kullberg, B. J. ^{[12
]}

Lass-Floerl, C. ^{[16
]}

Lortholary, O. ^{[17
,18
]}

Meersseman, W. ^{[19
]}

Petrikkos, G. ^{[20
]}

Richardson, M. D. ^{[21
,22
]}

Verweij, P. E. ^{[12
]}

Viscoli, C. ^{[23
]}

Ullmann, A. J. ^{[24
]}

机构：

[1] Univ Liverpool, Dept Mol & Clin Pharmacol, Liverpool L69 3GE, Merseyside, England

[2] Childrens Hosp, Inst Giannina Gaslini, Genoa, Italy

[3] Univ Childrens Hosp, Ctr Bone Marrow Transplantat, Dept Pediat Hematol Oncol, Munster, Germany

[4] Aristotle Univ Thessaloniki, Sch Med, Dept Pediat 3, Hippokrat Hosp, GR-54006 Thessaloniki, Greece

[5] Hacettepe Univ, Sch Med, Dept Med, Ankara, Turkey

[6] Statens Serum Inst, DK-2300 Copenhagen, Denmark

[7] Hacettepe Univ, Sch Med, Dept Med Microbiol, Ankara, Turkey

[8] Santa Maria Misericordia Univ Hosp, Udine, Italy

[9] CHU Vaudois, CH-1011 Lausanne, Switzerland

[10] Univ Cologne, Dept Internal Med 1,Cologne Excellence Cluster Ce, Clin Trials Ctr Cologne,ZKS Koln,German Ctr Infec, BMBF 01KN1106,Ctr Integrated Oncol CIO KolnBonn, D-50931 Cologne, Germany

[11] Inst Salud Carlos III, Ctr Nacl Microbiol, Madrid, Spain

[12] Radboud Univ Nijmegen, Med Ctr, NL-6525 ED Nijmegen, Netherlands

[13] Univ Hosp Geneva, Geneva, Switzerland

[14] Univ Strasbourg, Hop Hautepierre, Strasbourg, France

[15] Univ Copenhagen, Frederiksberg, Denmark

[16] Innsbruck Med Univ, Div Hyg & Med Microbiol, Innsbruck, Austria

[17] Univ Paris 05, Hop Necker Enfants Malad, APHP,IHU Imagine, Serv Malad Infect & Trop,Ctr Infectiol Necker Pas, Paris, France

[18] Inst Pasteur, CNRS, URA3012, Ctr Natl Reference Mycol & Antifong,Unite Mycol M, Paris, France

[19] Univ Hosp Gasthuisberg, B-3000 Louvain, Belgium

[20] Natl & Kapodistrian Univ Athens, Dept Internal Med 4, Athens 11528, Greece

[21] Univ S Manchester Hosp, Mycol Reference Ctr, Manchester M20 8LR, Lancs, England

[22] Univ Manchester, Manchester Acad Hlth Sci Ctr, Manchester, Lancs, England

[23] Univ Genoa, IRCCS San Martino IST, Genoa, Italy

[24] Univ Wurzburg, Dept Internal Med 2, D-97080 Wurzburg, Germany

来源：

CLINICAL MICROBIOLOGY AND INFECTION | 2012年 / 18卷

基金：

英国医学研究理事会;

关键词：

Antifungal agents; candida disease; children; Europe; neonates; LIPOSOMAL AMPHOTERICIN-B; LOW-BIRTH-WEIGHT; EMPIRICAL ANTIFUNGAL THERAPY; ITRACONAZOLE ORAL SOLUTION; STEM-CELL TRANSPLANTATION; CRITICALLY-ILL PATIENTS; CARE-UNIT PATIENTS; FUNGAL-INFECTIONS; FLUCONAZOLE PROPHYLAXIS; PEDIATRIC-PATIENTS;

D O I：

10.1111/1469-0691.12040

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

Clin Microbiol Infect 2012; 18 (Suppl. 7): 3852 Abstract Invasive candidiasis (IC) is a relatively common syndrome in neonates and children and is associated with significant morbidity and mortality. These guidelines provide recommendations for the prevention and treatment of IC in neonates and children. Appropriate agents for the prevention of IC in neonates at high risk include fluconazole (A-I), nystatin (B-II) or lactoferrin +/- Lactobacillus (B-II). The treatment of IC in neonates is complicated by the high likelihood of disseminated disease, including the possibility of infection within the central nervous system. Amphotericin B deoxycholate (B-II), liposomal amphotericin B (B-II), amphotericin B lipid complex (ABLC) (C-II), fluconazole (B-II), micafungin (B-II) and caspofungin (C-II) can all be potentially used. Recommendations for the prevention of IC in children are largely extrapolated from studies performed in adults with concomitant pharmacokinetic data and models in children. For allogeneic HSCT recipients, fluconazole (A-I), voriconazole (A-I), micafungin (A-I), itraconazole (B-II) and posaconazole (B-II) can all be used. Similar recommendations are made for the prevention of IC in children in other risk groups. With several exceptions, recommendations for the treatment of IC in children are extrapolated from adult studies, with concomitant pharmacokinetic studies. Amphotericin B deoxycholate (C-I), liposomal amphotericin B (A-I), ABLC (B-II), micafungin (A-I), caspofungin (A-I), anidulafungin (B-II), fluconazole (B-I) and voriconazole (B-I) can all be used.

引用

页码：38 / 52

页数：15

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