Construction of novel steroidal isoxazolidinone derivatives under Vilsmeier-Haack conditions

被引：19

作者：

Shamsuzzaman ^{[1
]}

Khanam, Hena ^{[1
]}

Mashrai, Ashraf ^{[1
]}

Siddiqui, Nazish ^{[2
]}

机构：

[1] Aligarh Muslim Univ, Dept Chem, Aligarh 202002, Uttar Pradesh, India

[2] Aligarh Muslim Univ, Dept Illmul, Advia Ajmal Khan Tibbiya Coll, Aligarh 202002, Uttar Pradesh, India

来源：

TETRAHEDRON LETTERS | 2013年 / 54卷 / 08期

关键词：

6-Hydroxyiminocholestane; Isoxazolidinone; Vilsmeier reagent; Steroid; FUSED PYRIDINES; QUINOLINES; VERSATILE; 4-METHYLIDENEISOXAZOLIDIN-5-ONES; CONVERSION;

D O I：

10.1016/j.tetlet.2012.11.105

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A novel expeditious and convenient synthesis of 5 alpha-cholestano-[5,6-c]-isoxazolidin-5'-ones based on the reaction of 5 alpha-6-hydroxyiminocholestanes with Vilsmeier-Haack reagent (DMF/POC1(3)) is described. The systems presented here, are novel scaffolds and have not been described before. Structural assignment of newly synthesized compounds was performed by IR, H-1 NMR, C-13 NMR, 2D H-1-H-1 COSY, MS and analytical data. (C) 2012 Elsevier Ltd. All rights reserved.

引用

页码：874 / 877

页数：4

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