Graphene oxide-photosensitizer conjugate as a redox-responsive theranostic agent

被引：85
作者：
Cho, Youngnam [1 ,2 ]
Choi, Yongdoo [1 ]
机构：
[1] Natl Canc Ctr, Mol Imaging & Therapy Branch, Goyang Si 410769, Gyeonggi Do, South Korea
[2] Purdue Univ, Ctr Paralysis Res, Dept Basic Med Sci, W Lafayette, IN 47907 USA
来源：
CHEMICAL COMMUNICATIONS | 2012年 / 48卷 / 79期
关键词：
DRUG-DELIVERY; THERAPY;
D O I：
10.1039/c2cc35197h
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
A nano-sized graphene oxide-photosensitizer conjugate with a redox-responsive cleavable disulfide linker is non-fluorescent and non-phototoxic, even upon light irradiation. It becomes highly fluorescent and phototoxic inside cancer cells, where glutathione is used as an initiator for activating the photosensitizer.
引用
收藏
页码：9912 / 9914
页数：3
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