Ablation of B7-H3 but Not B7-H4 Results in Highly Increased Tumor Burden in a Murine Model of Spontaneous Prostate Cancer

被引：42

作者：

Kreymborg, Katharina ^{[1
,2
]}

Haak, Stefan ^{[3
,4
,5
]}

Murali, Rajmohan ^{[6
,7
]}

Wei, Joyce ^{[8
]}

Waitz, Rebecca ^{[1
,2
]}

Gasteiger, Georg ^{[1
,2
]}

Savage, Peter A. ^{[9
]}

van den Brink, Marcel R. M. ^{[10
]}

Allison, James P. ^{[1
,2
,8
]}

机构：

[1] Mem Sloan Kettering Canc Ctr, Howard Hughes Med Inst, Program Immunol, New York, NY 10021 USA

[2] Mem Sloan Kettering Canc Ctr, Ludwig Ctr Canc Immunotherapy, New York, NY 10021 USA

[3] Columbia Univ, Med Ctr, New York, NY USA

[4] Tech Univ Munich, Ctr Allergy & Environm ZAUM, D-80290 Munich, Germany

[5] Helmholtz Ctr Munich, Munich, Germany

[6] Mem Sloan Kettering Canc Ctr, Dept Pathol, New York, NY 10021 USA

[7] Mem Sloan Kettering Canc Ctr, Human Oncol & Pathogenesis Program, New York, NY 10021 USA

[8] Univ Texas MD Anderson Canc Ctr, Dept Immunol, Houston, TX 77030 USA

[9] Univ Chicago, Dept Pathol, Chicago, IL 60637 USA

[10] Mem Sloan Kettering Canc Ctr, Dept Immunol & Med, New York, NY 10021 USA

来源：

CANCER IMMUNOLOGY RESEARCH | 2015年 / 3卷 / 08期

基金：

瑞士国家科学基金会;

关键词：

REGULATORY T-CELLS; IFN-GAMMA; B7; FAMILY; EXPRESSION; IMMUNOTHERAPY; MEMBER; MOUSE;

D O I：

10.1158/2326-6066.CIR-15-0100

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The costimulatory molecules B7-H3 and B7-H4 are over-expressed in a variety of human tumors and have been hypothesized as possible biomarkers and immunotherapeutic targets. Despite this potential, the predominating uncertainty about their functional implication in tumor-host interaction hampers their evaluation as a target for cancer therapy. By means of a highly physiologic, spontaneous tumor model in mice, we establish a causal link between B7-H3 and host tumor control and found B7-H4 to be redundant.

引用

页码：849 / 854

页数：6

共 19 条

[1] B7-H3:: A costimulatory molecule for T cell activation and IFN-γ production [J].

Chapoval, AI ;

Ni, J ;

Lau, JS ;

Wilcox, RA ;

Flies, DB ;

Liu, D ;

Dong, HD ;

Sica, GL ;

Zhu, GF ;

Tamada, K ;

Chen, LP .

NATURE IMMUNOLOGY, 2001, 2 (03) :269-274

[2] Induced expression of B7-H3 on the lung cancer cells and macrophages suppresses T-cell mediating anti-tumor immune response [J].

Chen, Cheng ;

Shen, Yu ;

Qu, Qiu-Xia ;

Chen, Xu-Qin ;

Zhang, Xue-Guang ;

Huang, Jian-An .

EXPERIMENTAL CELL RESEARCH, 2013, 319 (01) :96-102

[3] Specific recruitment of regulatory T cells in ovarian carcinoma fosters immune privilege and predicts reduced survival [J].

Curiel, TJ ;

Coukos, G ;

Zou, LH ;

Alvarez, X ;

Cheng, P ;

Mottram, P ;

Evdemon-Hogan, M ;

Conejo-Garcia, JR ;

Zhang, L ;

Burow, M ;

Zhu, Y ;

Wei, S ;

Kryczek, I ;

Daniel, B ;

Gordon, A ;

Myers, L ;

Lackner, A ;

Disis, ML ;

Knutson, KL ;

Chen, LP ;

Zou, WP .

NATURE MEDICINE, 2004, 10 (09) :942-949

[4] PROSTATE-CANCER IN A TRANSGENIC MOUSE [J].

GREENBERG, NM ;

DEMAYO, F ;

FINEGOLD, MJ ;

MEDINA, D ;

TILLEY, WD ;

ASPINALL, JO ;

CUNHA, GR ;

DONJACOUR, AA ;

MATUSIK, RJ ;

ROSEN, JM .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1995, 92 (08) :3439-3443

[5] Improved Survival with Ipilimumab in Patients with Metastatic Melanoma [J].

Hodi, F. Stephen ;

O'Day, Steven J. ;

McDermott, David F. ;

Weber, Robert W. ;

Sosman, Jeffrey A. ;

Haanen, John B. ;

Gonzalez, Rene ;

Robert, Caroline ;

Schadendorf, Dirk ;

Hassel, Jessica C. ;

Akerley, Wallace ;

van den Eertwegh, Alfons J. M. ;

Lutzky, Jose ;

Lorigan, Paul ;

Vaubel, Julia M. ;

Linette, Gerald P. ;

Hogg, David ;

Ottensmeier, Christian H. ;

Lebbe, Celeste ;

Peschel, Christian ;

Quirt, Ian ;

Clark, Joseph I. ;

Wolchok, Jedd D. ;

Weber, Jeffrey S. ;

Tian, Jason ;

Yellin, Michael J. ;

Nichol, Geoffrey M. ;

Hoos, Axel ;

Urba, Walter J. .

NEW ENGLAND JOURNAL OF MEDICINE, 2010, 363 (08) :711-723

[6] Animal Models of Human Prostate Cancer: The Consensus Report of the New York Meeting of the Mouse Models of Human Cancers Consortium Prostate Pathology Committee [J].

Ittmann, Michael ;

Huang, Jiaoti ;

Radaelli, Enrico ;

Martin, Philip ;

Signoretti, Sabina ;

Sullivan, Ruth ;

Simons, Brian W. ;

Ward, Jerrold M. ;

Robinson, Brian D. ;

Chu, Gerald C. ;

Loda, Massimo ;

Thomas, George ;

Borowsky, Alexander ;

Cardiff, Robert D. .

CANCER RESEARCH, 2013, 73 (09) :2718-2736

[7] Demonstration of an interferon γ-dependent tumor surveillance system in immunocompetent mice [J].

Kaplan, DH ;

Shankaran, V ;

Dighe, AS ;

Stockert, E ;

Aguet, M ;

Old, LJ ;

Schreiber, RD .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1998, 95 (13) :7556-7561

[8] Endothelial CD276 (B7-H3) expression is increased in human malignancies and distinguishes between normal and tumour-derived circulating endothelial cells [J].

Kraan, J. ;

van den Broek, P. ;

Verhoef, C. ;

Grunhagen, D. J. ;

Taal, W. ;

Gratama, J. W. ;

Sleijfer, S. .

BRITISH JOURNAL OF CANCER, 2014, 111 (01) :149-156

[9] B7-H3 and Its Role in Antitumor Immunity [J].

Loos, Martin ;

Hedderich, Dennis M. ;

Friess, Helmut ;

Kleeff, Joerg .

CLINICAL & DEVELOPMENTAL IMMUNOLOGY, 2010,

[10] Regulatory T cells in cancer immunotherapy [J].

Nishikawa, Hiroyoshi ;

Sakaguchi, Shimon .

CURRENT OPINION IN IMMUNOLOGY, 2014, 27 :1-7

← 1 2 →