Ablation of B7-H3 but Not B7-H4 Results in Highly Increased Tumor Burden in a Murine Model of Spontaneous Prostate Cancer

被引：42

作者：

Kreymborg, Katharina ^{[1
,2
]}

Haak, Stefan ^{[3
,4
,5
]}

Murali, Rajmohan ^{[6
,7
]}

Wei, Joyce ^{[8
]}

Waitz, Rebecca ^{[1
,2
]}

Gasteiger, Georg ^{[1
,2
]}

Savage, Peter A. ^{[9
]}

van den Brink, Marcel R. M. ^{[10
]}

Allison, James P. ^{[1
,2
,8
]}

机构：

[1] Mem Sloan Kettering Canc Ctr, Howard Hughes Med Inst, Program Immunol, New York, NY 10021 USA

[2] Mem Sloan Kettering Canc Ctr, Ludwig Ctr Canc Immunotherapy, New York, NY 10021 USA

[3] Columbia Univ, Med Ctr, New York, NY USA

[4] Tech Univ Munich, Ctr Allergy & Environm ZAUM, D-80290 Munich, Germany

[5] Helmholtz Ctr Munich, Munich, Germany

[6] Mem Sloan Kettering Canc Ctr, Dept Pathol, New York, NY 10021 USA

[7] Mem Sloan Kettering Canc Ctr, Human Oncol & Pathogenesis Program, New York, NY 10021 USA

[8] Univ Texas MD Anderson Canc Ctr, Dept Immunol, Houston, TX 77030 USA

[9] Univ Chicago, Dept Pathol, Chicago, IL 60637 USA

[10] Mem Sloan Kettering Canc Ctr, Dept Immunol & Med, New York, NY 10021 USA

来源：

CANCER IMMUNOLOGY RESEARCH | 2015年 / 3卷 / 08期

基金：

瑞士国家科学基金会;

关键词：

REGULATORY T-CELLS; IFN-GAMMA; B7; FAMILY; EXPRESSION; IMMUNOTHERAPY; MEMBER; MOUSE;

D O I：

10.1158/2326-6066.CIR-15-0100

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The costimulatory molecules B7-H3 and B7-H4 are over-expressed in a variety of human tumors and have been hypothesized as possible biomarkers and immunotherapeutic targets. Despite this potential, the predominating uncertainty about their functional implication in tumor-host interaction hampers their evaluation as a target for cancer therapy. By means of a highly physiologic, spontaneous tumor model in mice, we establish a causal link between B7-H3 and host tumor control and found B7-H4 to be redundant.

引用

页码：849 / 854

页数：6

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