Long non-coding RNA H19 in atherosclerosis: what role?

被引：37

作者：

Shi, Xian ^{[1
]}

Wei, Ya-Ting ^{[1
]}

Li, Heng ^{[2
]}

Jiang, Ting ^{[3
]}

Zheng, Xi-Long ^{[4
,5
]}

Yin, Kai ^{[6
]}

Zhao, Guo-Jun ^{[3
]}

机构：

[1] Guilin Med Univ, Sch Med, Guilin 541100, Guangxi, Peoples R China

[2] Univ South China, Inst Cardiovasc Res, Key Lab Arteriosclerol Hunan Prov, Hengyang 421001, Hunan, Peoples R China

[3] Guangzhou Med Univ, Qingyuan City Peoples Hosp, Affiliated Hosp 6, Qingyuan 511518, Guangdong, Peoples R China

[4] Univ Calgary, Libin Cardiovasc Inst Alberta, Dept Biochem & Mol Biol, Hlth Sci Ctr, Calgary, AB, Canada

[5] Guangzhou Med Univ, Sch Pharmaceut Sci, Key Lab Mol Targets & Clin Pharmacol, Guangzhou 511436, Guangdong, Peoples R China

[6] Guilin Med Univ, Guangxi Key Lab Excellence, Ctr Diabet Syst Med, Affiliated Hosp 2, Guilin 541100, Guangxi, Peoples R China

来源：

MOLECULAR MEDICINE | 2020年 / 26卷 / 01期

关键词：

LncRNA-H19; Angiogenesis; Lipid metabolism; Inflammatory response; Atherosclerosis; PERIVASCULAR ADIPOSE-TISSUE; MESENCHYMAL STEM-CELLS; SMOOTH-MUSCLE-CELLS; NF-KAPPA-B; ENDOTHELIAL GROWTH-FACTOR; LNCRNA H19; ANGIOGENESIS; INJURY; PROMOTES; AXIS;

D O I：

10.1186/s10020-020-00196-w

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Atherosclerosis (AS) is widely accepted to be a multistep pathophysiological process associated with several other processes such as angiogenesis and inflammatory response. Long non-coding RNAs (lncRNAs) are non-protein coding RNAs (more than 200 nucleotides in length) and can regulate gene expression at the transcriptional and post-transcriptional levels. Recent studies suggest that lncRNA-H19 plays important roles in the regulation of angiogenesis, adipocyte differentiation, lipid metabolism, inflammatory response, cellular proliferation and apoptosis. In this review, we primarily discuss the roles of lncRNA-H19 in atherosclerosis-related pathophysiological processes and the potential mechanisms by which lncRNA-H19 regulates the development of atherosclerosis, to help provide a better understanding of the biological functions of lncRNA-H19 in atherosclerosis.

引用

页数：12

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