Delineation of the primary tumour Clinical Target Volumes (CTV-P) in laryngeal, hypopharyngeal, oropharyngeal and oral cavity squamous cell carcinoma: AIRO, CACA, DAHANCA, EORTC, GEORCC, GORTEC, HKNPCSG, HNCIG, IAG-KHT, LPRHHT, NCIC CTG, NCRI, NRG Oncology, PHNS, SBRT, SOMERA, SRO, SSHNO, TROG consensus guidelines

被引：280

作者：

Gregoire, Vincent ^{[1
]}

Evans, Mererid ^{[2
]}

Quynh-Thu Le ^{[3
]}

Bourhis, Jean ^{[4
,5
]}

Budach, Volker ^{[6
]}

Chen, Amy ^{[7
]}

Eisbruch, Abraham ^{[8
]}

Feng, Mei ^{[9
]}

Giralt, Jordi ^{[10
]}

Gupta, Tejpal ^{[11
]}

Hamoir, Marc ^{[12
]}

Helito, Juliana K. ^{[13
]}

Hu, Chaosu ^{[14
]}

Hunter, Keith ^{[15
,16
]}

Johansen, Jorgen

Kaanders, Johannes ^{[17
]}

Laskar, Sarbani Ghosh ^{[11
]}

Lee, Anne ^{[18
,19
]}

Maingon, Philippe ^{[20
]}

Makitie, Antti ^{[21
,22
]}

Micciche, Francesco ^{[23
]}

Nicolai, Piero ^{[24
]}

O'Sullivan, Brian ^{[25
]}

Poitevin, Adela ^{[26
]}

Porceddu, Sandro ^{[27
]}

Skiadowski, Krzysztof ^{[28
]}

Tribius, Silke ^{[29
]}

Waldron, John ^{[25
]}

Wee, Joseph ^{[30
]}

Yao, Min ^{[31
]}

Yom, Sue S. ^{[32
]}

Zimmermann, Frank ^{[33
]}

Grau, Cai ^{[34
]}

机构：

[1] Catholic Univ Louvain, St Luc Univ Hosp, Dept Radiat Oncol, Brussels, Belgium

[2] Velindre Canc Ctr, Dept Radiat Oncol, Cardiff, S Glam, Wales

[3] Stanford Univ, Sch Med, Dept Radiat Oncol, Stanford, CA 94305 USA

[4] CHU Vaudois, Lausanne, Switzerland

[5] Univ Lausanne, Dept Radiat Oncol, Lausanne, Switzerland

[6] Charite, Dept Radiooncol & Radiotherapy, Berlin, Germany

[7] Sun Yat Sen Univ, Dept Radiat Oncol, Canc Ctr, Guangzhou, Guangdong, Peoples R China

[8] Univ Michigan Hlth Syst, Dept Radiat Oncol, Ann Arbor, MI USA

[9] Sichuan Canc Hosp, Dept Radiat Oncol, Chengdu, Sichuan, Peoples R China

[10] Vall Hebron Univ Hosp, Radiat Oncol Serv, Barcelona, Spain

[11] Tata Mem Hosp, Dept Radiat Oncol, Bombay, Maharashtra, India

[12] Catholic Univ Louvain, St Luc Univ Hosp, Dept Head & Neck Surg, Brussels, Belgium

[13] Hosp Israelita Albert Einstein, Dept Radiat Oncol, Sao Paulo, Brazil

[14] Fudan Univ, Dept Radiat Oncol, Shanghai Canc Ctr, Shanghai, Peoples R China

[15] Univ Sheffield, Sch Clin Dent, Unit Oral & Maxillofacial Pathol, Sheffield, S Yorkshire, England

[16] Odense Univ Hosp, Dept Oncol, Odense, Denmark

[17] Radboud Univ Nijmegen, Dept Radiat Oncol, Med Ctr, Nijmegen, Netherlands

[18] Univ Hong Kong, Hong Kong, Hong Kong, Peoples R China

[19] Univ Hong Kong, Shenzhen Hosp, Dept Clin Oncol, Hong Kong, Hong Kong, Peoples R China

[20] Hop Univ Pitie Salpetriere Charles Foix, Dept Radiat Oncol, Paris, France

[21] Univ Helsinki, Helsinki, Finland

[22] Helsinki Univ Hosp, Dept Otorhinolaryngol Head & Neck Surg, Helsinki, Finland

[23] Univ Cattolica Sacro Cuore, Fdn Policlin Univ Agostino Gemelli, Polo Sci Oncol Ematol, Rome, Italy

[24] Univ Brescia, Div Otorhinolaryngol Head & Neck Surg, Brescia, Italy

[25] Univ Toronto, Princess Margaret Hosp, Dept Radiat Oncol, Toronto, ON, Canada

[26] Med Sur, Unit Radiotherapy, Mexico City, DF, Mexico

[27] Princess Alexander Hosp, Dept Radiat Oncol, Brisbane, Qld, Australia

[28] Maria Sklodowska Curie Canc Ctr, Inst Oncol, Gliwice, Poland

[29] Asklepios St Georg Hosp, Hermann Holthusen Inst Radiotherapy, Hamburg, Germany

[30] Natl Canc Ctr Singapore, Div Radiat Oncol, Singapore, Singapore

[31] Case Western Reserve Univ Hosp, Dept Radiat Oncol, Cleveland, OH 44106 USA

[32] Univ Calif San Francisco, Dept Radiat Oncol, San Francisco, CA USA

[33] Univ Hosp Basel, Clin Radiotherapy & Radiat Oncol, Basel, Switzerland

[34] Aarhus Univ Hosp, Dept Oncol, Aarhus, Denmark

来源：

RADIOTHERAPY AND ONCOLOGY | 2018年 / 126卷 / 01期

关键词：

Clinical Target Volume (CTV); Gross Tumour Volume (GTV); Radiotherapy; Head and neck; Guideline; NECK-CANCER; RADIATION-THERAPY; ADVANCED HEAD; NODE LEVELS; FDG-PET; RADIOTHERAPY; CLASSIFICATION; PROPOSAL; MARGINS; IMPACT;

D O I：

10.1016/j.radonc.2017.10.016

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Purpose: Few studies have reported large inter-observer variations in target volume selection and delineation in patients treated with radiotherapy for head and neck squamous cell carcinoma. Consensus guidelines have been published for the neck nodes (see Gregoire et al., 2003, 2014), but such recommendations are lacking for primary tumour delineation. For the latter, two main schools of thoughts are prevailing, one based on geometric expansion of the Gross Tumour Volume (GTV) as promoted by DAHANCA, and the other one based on anatomical expansion of the GTV using compartmentalization of head and neck anatomy. Method: For each anatomic location within the larynx, hypopharynx, oropharynx and oral cavity, and for each T-stage, the DAHANCA proposal has been comprehensively reviewed and edited to include anatomic knowledge into the geometric Clinical Target Volume (CTV) delineation concept. A first proposal was put forward by the leading authors of this publication (VG and CG) and discussed with opinion leaders in head and neck radiation oncology from Europe, Asia, Australia/New Zealand, North America and South America to reach a worldwide consensus. Results: This consensus proposes two CTVs for the primary tumour, the so called CTV-P1 and CVT-P2, corresponding to a high and lower tumour burden, and which should be associated with a high and a lower dose prescription, respectively. Conclusion: Implementation of these guidelines in the daily practice of radiation oncology should contribute to reduce treatment variations from clinicians to clinicians, facilitate the conduct of multi institutional clinical trials, and contribute to improved care of patients with head and neck carcinoma. (C) 2017 Elsevier B.V. All rights reserved.

引用

页码：3 / 24

页数：22

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