A practical synthesis of 2,3-dihydro-1,5-benzothiazepines

被引：27

作者：

Albanese, Domenico C. M. ^{[1
]}

Gaggero, Nicoletta ^{[2
]}

Fei, Meng ^{[2
]}

机构：

[1] Univ Milan, Dept Chem, Via C Golgi 19, I-20133 Milan, Italy

[2] Univ Milan, Dept Pharmaceut Sci, Via L Mangiagalli 25, I-20133 Milan, Italy

来源：

GREEN CHEMISTRY | 2017年 / 19卷 / 23期

关键词：

EFFICIENT SYNTHESIS; MICHAEL ADDITION; HIGHLY EFFICIENT; CATALYST; DISULFIDES; 1,5-BENZOTHIAZEPINES; 1,5-BENZODIAZEPINES; LIMITATIONS; OXIDATION; ALCOHOLS;

D O I：

10.1039/c7gc02097j

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

2,3-Dihydro-1,5-benzothiazepines have been obtained through a domino process involving a Michael addition of 2-aminothiophenols to chalcones, followed by in situ cyclization. Up to 98% chemical yields have been obtained at room temperature under essentially neutral conditions by using hexafluoro-2propanol as an efficient medium.

引用

页码：5703 / 5707

页数：5

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