INVESTIGATING THE IMPACT OF ENZYME CORRELATIONS ON INTER-INDIVIDUAL VARIABILITY IN PHARMACOKINETICS AND DRUG-DRUG INTERACTIONS

被引：0
作者：
Hatley, Oliver [1 ]
Ezuruike, Udoamaka [1 ]
Wedagedera, Janak [1 ]
Takahashi, Ryan [2 ]
Mao, Jialin [2 ]
Gardner, Iain [1 ]
机构：
[1] Certara UK, Simcyp Div, Sheffield, S Yorkshire, England
[2] Genentech Inc, San Francisco, CA 94080 USA
来源：
DRUG METABOLISM AND PHARMACOKINETICS | 2020年 / 35卷 / 01期
关键词：
HUMAN LIVER; ABUNDANCE;
D O I：
暂无
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
P214
引用
收藏
页码：S87 / S87
页数：1
相关论文
共 3 条
[1]   Simultaneous Quantification of the Abundance of Several Cytochrome P450 and Uridine 5′-Diphospho-Glucuronosyltransferase Enzymes in Human Liver Microsomes Using Multiplexed Targeted Proteomics [J].
Achour, Brahim ;
Russell, Matthew R. ;
Barber, Jill ;
Rostami-Hodjegan, Amin .
DRUG METABOLISM AND DISPOSITION, 2014, 42 (04) :500-510
[2]   Population-Based Mechanistic Prediction of Oral Drug Absorption [J].
Jamei, Masoud ;
Turner, David ;
Yang, Jiansong ;
Neuhoff, Sibylle ;
Polak, Sebastian ;
Rostami-Hodjegan, Amin ;
Tucker, Geoffrey .
AAPS JOURNAL, 2009, 11 (02) :225-237
[3]  
Yeo KR, 2004, BRIT J CLIN PHARMACO, V57, P687
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