Emerging strategies in peripheral T-cell lymphoma

被引:0
作者
Mehta-Shah, Neha [1 ]
机构
[1] Washington Univ, 660 S Euclid,Box 8056, St Louis, MO 63132 USA
关键词
BRENTUXIMAB VEDOTIN; PHASE-II; KINASE; MODELS; LINE;
D O I
暂无
中图分类号
G40 [教育学];
学科分类号
040101 ; 120403 ;
摘要
Peripheral T-cell lymphomas (PTCLs) are a heterogenous group of aggressive non-Hodgkin lymphomas that are less chemosensitive than their B-cell counterparts. Until recently, standard therapy did not distinguish between subtypes, and deeper understanding of the biology of these diseases was lacking. The availability of targeted therapy and more sophisticated subtype classification has translated into the development of novel treatment options for these rare diseases. This includes the development of a brentuximab vedotin-based upfront chemotherapy regimen that confers an overall survival benefit for a subset of patients. Clinical trials of targeted agents, as well as development of better preclinical models of PTCL, are leading to therapeutic advances in the field, including the development of phosphoinositide-3-kinase inhibitors, histone deacetylase inhibitor-based strategies, CD30-directed strategies, Janus kinase inhibitors, and spleen-associated tyrosine kinase inhibitors. Better understanding of the biology of these diseases based on gene expression profiling, minimal residual disease evaluation, and modeling in patient-derived xenografts should help define mechanisms of response and resistance to therapy. Given the complex biology of these heterogeneous lymphomas, well-tolerated combination strategies targeted toward specific subtypes of PTCL can lead to advances in the field. Similar to the story of brentuximab vedotin, development of effective therapies in the salvage setting will likely lead to improved upfront strategies in PTCLs, and ultimately a more personalized approach.
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页码:41 / 46
页数:6
相关论文
共 45 条
[1]   A phase II study of cyclophosphamide, etoposide, vincristine and prednisone (CEOP) Alternating with Pralatrexate (P) as front line therapy for patients with peripheral T-cell lymphoma (PTCL): final results from the T- cell consortium trial [J].
Advani, Ranjana H. ;
Ansell, Stephen M. ;
Lechowicz, Mary J. ;
Beaven, Anne W. ;
Loberiza, Fausto ;
Carson, Kenneth R. ;
Evens, Andrew M. ;
Foss, Francine ;
Horwitz, Steven ;
Pro, Barbara ;
Pinter-Brown, Lauren C. ;
Smith, Sonali M. ;
Shustov, Andrei R. ;
Savage, Kerry J. ;
Vose, Julie M. .
BRITISH JOURNAL OF HAEMATOLOGY, 2016, 172 (04) :535-544
[2]   Inactivation of PI(3)K p110δ breaks regulatory T-cell-mediated immune tolerance to cancer [J].
Ali, Khaled ;
Soond, Dalya R. ;
Pineiro, Roberto ;
Hagemann, Thorsten ;
Pearce, Wayne ;
Lim, Ee Lyn ;
Bouabe, Hicham ;
Scudamore, Cheryl L. ;
Hancox, Timothy ;
Maecker, Heather ;
Friedman, Lori ;
Turner, Martin ;
Okkenhaug, Klaus ;
Vanhaesebroeck, Bart .
NATURE, 2014, 510 (7505) :407-+
[3]  
Altmann B., 2018, Blood, V132, P1622
[4]   A phase 1 study of romidepsin and pralatrexate reveals marked activity in relapsed and refractory T-cell lymphoma [J].
Amengual, Jennifer E. ;
Lichtenstein, Renee ;
Lue, Jennifer ;
Sawas, Ahmed ;
Deng, Changchun ;
Lichtenstein, Emily ;
Khan, Karen ;
Atkins, Laine ;
Rada, Aishling ;
Kim, Hye A. ;
Chiuzan, Codruta ;
Kalac, Matko ;
Marchi, Enrica ;
Falchi, Lorenzo ;
Francescone, Mark A. ;
Schwartz, Lawrence ;
Cremers, Serge ;
O'Connor, Owen A. .
BLOOD, 2018, 131 (04) :397-407
[5]  
[Anonymous], 2017, BLOOD S1
[6]  
[Anonymous], 2018, ASH ANN M
[7]   IRF4 Mediates the Oncogenic Effects of STAT3 in Anaplastic Large Cell Lymphomas [J].
Bandini, Cecilia ;
Pupuleku, Aldi ;
Spaccarotella, Elisa ;
Pellegrino, Elisa ;
Wang, Rui ;
Vitale, Nicoletta ;
Duval, Carlotta ;
Cantarella, Daniela ;
Rinaldi, Andrea ;
Provero, Paolo ;
Di Cunto, Ferdinando ;
Medico, Enzo ;
Bertoni, Francesco ;
Inghirami, Giorgio ;
Piva, Roberto .
CANCERS, 2018, 10 (01)
[8]   The anaplastic lymphoma kinase in the pathogenesis of cancer [J].
Chiarle, Roberto ;
Voena, Claudia ;
Ambrogio, Chiara ;
Piva, Roberto ;
Inghirami, Giorgio .
NATURE REVIEWS CANCER, 2008, 8 (01) :11-23
[9]   Up-Front Autologous Stem-Cell Transplantation in Peripheral T-Cell Lymphoma: NLG-T-01 [J].
d'Amore, Francesco ;
Relander, Thomas ;
Lauritzsen, Grete F. ;
Jantunen, Esa ;
Hagberg, Hans ;
Anderson, Harald ;
Holte, Harald ;
Osterborg, Anders ;
Merup, Mats ;
Brown, Peter ;
Kuittinen, Outi ;
Erlanson, Martin ;
Ostenstad, Bjorn ;
Fagerli, Unn-Merete ;
Gadeberg, Ole V. ;
Sundstrom, Christer ;
Delabie, Jan ;
Ralfkiaer, Elisabeth ;
Vornanen, Martine ;
Toldbod, Helle E. .
JOURNAL OF CLINICAL ONCOLOGY, 2012, 30 (25) :3093-3099
[10]  
DELARUE R, 2016, BLOOD, V128