Repeated treatment with SA4503, a selective sigma1 receptor agonist, up-regulates α1-adrenergic system.: A behavioral study

被引:0
作者
Skuza, G [1 ]
Kolasiewicz, W [1 ]
机构
[1] Polish Acad Sci, Inst Pharmacol, Dept Pharmacol, PL-31343 Krakow, Poland
来源
POLISH JOURNAL OF PHARMACOLOGY | 2001年 / 53卷 / 05期
关键词
sigma; agonist; repeated treatment; phenylephrine; clonidine; behavioral models;
D O I
暂无
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
The obtained results indicate that SA4503, a selective sigma(1) receptor agonist, given repeatedly (but not acutely) enhanced the effects of phenylephrine, alpha (1)-adrenoceptor agonist, and clonidine (stimulating the postsynaptic alpha (1)-adrenoceptors at high dose) in behavioral models (hyperexploratory activity in rats and aggressiveness in mice, respectively).
引用
收藏
页码:547 / 550
页数:4
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