Integration of noninvasive prenatal prediction of fetal blood group into clinical prenatal care

被引:28
作者
Clausen, Frederik Banch [1 ]
机构
[1] Copenhagen Univ Hosp, Rigshosp, Lab Blood Genet, Dept Clin Immunol, Copenhagen, Denmark
关键词
NEGATIVE PREGNANT-WOMEN; ANTI-D PROPHYLAXIS; REAL-TIME PCR; CELL-FREE DNA; MATERNAL PLASMA; RHESUS-D; RHD STATUS; HYPERMETHYLATED RASSF1A; DIAGNOSTIC-ACCURACY; HEMOLYTIC-DISEASE;
D O I
10.1002/pd.4326
中图分类号
Q3 [遗传学];
学科分类号
071007 ; 090102 ;
摘要
Incompatibility of red blood cell blood group antigens between a pregnant woman and her fetus can cause maternal immunization and, consequently, hemolytic disease of the fetus and newborn. Noninvasive prenatal testing of cell-free fetal DNA can be used to assess the risk of hemolytic disease of the fetus and newborn to fetuses of immunized women. Prediction of the fetal RhD type has been very successful and is now integrated into clinical practice to assist in the management of the pregnancies of RhD immunized women. In addition, noninvasive prediction of the fetal RhD type can be applied to guide targeted prenatal prophylaxis, thus avoiding unnecessary exposure to anti-D in pregnant women. The analytical aspect of noninvasive fetal RHD typing is very robust and accurate, and its routine utilization has demonstrated high sensitivities for fetal RHD detection. A high compliance with administering anti-D is essential for obtaining a clinical effect. Noninvasive fetal typing of RHC/c, RHE/e, and KEL may become more widely used in the future. (c) 2014 John Wiley & Sons, Ltd.
引用
收藏
页码:409 / 415
页数:7
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