Self-assembled hybrid nanoparticles for targeted co-delivery of two drugs into cancer cells

被引：82
作者：
Huang, Fujian [1 ,2 ,3 ,4 ,5 ]
You, Mingxu [1 ,2 ,3 ,4 ,6 ,7 ]
Chen, Tao [1 ,2 ,3 ,4 ,6 ,7 ]
Zhu, Guizhi [1 ,2 ,3 ,4 ,6 ,7 ]
Liang, Haojun [5 ]
Tan, Weihong [1 ,2 ,3 ,4 ,6 ,7 ]
机构：
[1] Univ Florida, Shands Canc Ctr, Dept Chem, Gainesville, FL 32611 USA
[2] Univ Florida, Shands Canc Ctr, Dept Physiol & Funct Genom, Gainesville, FL 32611 USA
[3] Univ Florida, Ctr Res Interface Bio Nano, UF Genet Inst, Gainesville, FL 32611 USA
[4] Univ Florida, Ctr Res Interface Bio Nano, McKnight Brain Inst, Gainesville, FL 32611 USA
[5] Univ Sci & Technol China, Dept Polymer Sci & Engn, Collaborat Innovat Ctr Chem Energy Mat, CAS Key Lab Soft Matter Chem, Hefei 230026, Anhui, Peoples R China
[6] Hunan Univ, Coll Biol, State Key Lab Chemo Biosensing & Chemometr, Mol Sci & Biomed Lab, Changsha 410082, Hunan, Peoples R China
[7] Hunan Univ, Coll Chem & Chem Engn, Changsha 410082, Hunan, Peoples R China
来源：
CHEMICAL COMMUNICATIONS | 2014年 / 50卷 / 23期
基金：
中国国家自然科学基金; 美国国家卫生研究院;
关键词：
PLGA NANOPARTICLES; INDUCED APOPTOSIS; CELLULAR UPTAKE; PACLITAXEL; DOXORUBICIN; APTAMER; PHARMACOKINETICS; BIODISTRIBUTION; PROBES;
D O I：
10.1039/c3cc49003c
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
A therapeutic aptamer-lipid-poly(lactide-co-glycolic acid) hybrid nanoparticle-based drug delivery system was prepared and characterized. This system can co-deliver two different drugs with distinct solubility and different anticancer mechanisms to target cancer cells with high specificity and efficiency.
引用
收藏
页码：3103 / 3105
页数：3
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