Computational nanomedicine: modeling of nanoparticle-mediated hyperthermal cancer therapy

被引：0
作者：
Kaddi, Chanchala D. [1 ]
Phan, John H. [1 ]
Wang, May D. [2 ,3 ]
机构：
[1] Georgia Inst Technol, Wallace H Coulter Dept Biomed Engn, Atlanta, GA 30332 USA
[2] Georgia Inst Technol, Biomed Engn Dept, Winship Canc Inst, Parker H Petit Inst Bioengn & Biosci, Atlanta, GA 30332 USA
[3] Emory Univ, Atlanta, GA 30332 USA
来源：
NANOMEDICINE | 2013年 / 8卷 / 08期
基金：
美国国家科学基金会;
关键词：
bioinformatics; drug delivery; hyperthermia; mathematical modeling; nanomedicine; nanoparticle; pharmacokinetics; simulation; MAGNETIC NANOPARTICLES; PROSTATE-CANCER; GOLD-NANOPARTICLE; DRUG-DELIVERY; TUMOR; THERMOTHERAPY; FEASIBILITY; CHALLENGES; DYNAMICS; KINETICS;
D O I：
10.2217/NNM.13.117
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
Nanoparticle-mediated hyperthermia for cancer therapy is a growing area of cancer nanomedicine because of the potential for localized and targeted destruction of cancer cells. Localized hyperthermal effects are dependent on many factors, including nanoparticle size and shape, excitation wavelength and power, and tissue properties. Computational modeling is an important tool for investigating and optimizing these parameters. In this review, we focus on computational modeling of magnetic and gold nanoparticle-mediated hyperthermia, followed by a discussion of new opportunities and challenges.
引用
收藏
页码：1323 / 1333
页数：11
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