Understanding the Association of Apolipoprotein E4 with Alzheimer Disease: Clues from Its Structure

被引：108

作者：

Zhong, Ning ^{[1
]}

Weisgraber, Karl H. ^{[1
,2
,3
]}

机构：

[1] Gladstone Inst Neurol Dis, San Francisco, CA 94158 USA

[2] Univ Calif San Francisco, Dept Pathol, San Francisco, CA 94143 USA

[3] Univ Calif San Francisco, Cardiovasc Res Inst, San Francisco, CA 94143 USA

来源：

JOURNAL OF BIOLOGICAL CHEMISTRY | 2009年 / 284卷 / 10期

基金：

美国国家卫生研究院;

关键词：

AMINO-TERMINAL DOMAIN; NEURONAL CELLS; THERAPEUTIC TARGET; AQUEOUS-SOLUTION; TRANSGENIC MICE; MOLTEN GLOBULE; E GENOTYPE; IN-VITRO; PROTEIN; PEPTIDE;

D O I：

10.1074/jbc.R800009200

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Despite intense interest, the molecular mechanisms underlying the association of apoE4 with Alzheimer disease are not clear. Because the function (or dysfunction) of a protein is based on its structure, this review focuses on the effects of the structural differences among the isoforms on neurodegeneration. Understanding how apoE4 structure impacts neurodegeneration is likely to provide mechanistic insight as well as potential therapeutic approaches to blunt or reduce its effects.

引用

页码：6027 / 6031

页数：5

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