SARS-CoV-2 immunity: review and applications to phase 3 vaccine candidates

被引：425
作者：
Poland, Gregory A. [1 ,2 ]
Ovsyannikova, Inna G. [1 ,2 ]
Kennedy, Richard B. [1 ,2 ]
机构：
[1] Mayo Clin, Mayo Clin Vaccine Res Grp, Rochester, MN USA
[2] Mayo Clin, Div Gen Internal Med, Rochester, MN USA
来源：
LANCET | 2020年 / 396卷 / 10262期
关键词：
ANTIBODY-DEPENDENT ENHANCEMENT; COVID-19; INFECTION; DISEASE; CELLS;
D O I：
10.1016/S0140-6736(20)32137-1
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Understanding immune responses to severe acute respiratory syndrome coronavirus 2 is crucial to understanding disease pathogenesis and the usefulness of bridge therapies, such as hyperimmune globulin and convalescent human plasma, and to developing vaccines, antivirals, and monoclonal antibodies. A mere 11 months ago, the canvas we call COVID-19 was blank. Scientists around the world have worked collaboratively to fill in this blank canvas. In this Review, we discuss what is currently known about human humoral and cellular immune responses to severe acute respiratory syndrome coronavirus 2 and relate this knowledge to the COVID-19 vaccines currently in phase 3 clinical trials.
引用
收藏
页码：1595 / 1606
页数：12
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