Yeast homologue of neuronal frequenin is a regulator of phosphatidylinositol-4-OH kinase

被引：213
作者：
Hendricks, KB [1 ]
Wang, BQ [1 ]
Schnieders, EA [1 ]
Thorner, J [1 ]
机构：
[1] Univ Calif Berkeley, Dept Mol & Cell Biol, Div Biochem & Mol Biol, Berkeley, CA 94720 USA
来源：
NATURE CELL BIOLOGY | 1999年 / 1卷 / 04期
关键词：
D O I：
10.1038/12058
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
In metazoans, certain calmodulin-related calcium-binding proteins (recoverins, neurocalcins and frequenins) are found at highest levels in excitable cells, but their physiological roles are largely uncharacterized. Here we show that Saccharomyces cerevisiae contains a frequenin homologue, Frq1, and that its target is Pik1, a phosphatidylinositol-4-OH kinase. Frq1 binds to a conserved sequence motif in Pik1 outside Pik1's catalytic domain and stimulates its activity in vitro. N-myristoylated Frq1 may also assist in Pik1 localization.
引用
收藏
页码：234 / 241
页数：8
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