Yeast homologue of neuronal frequenin is a regulator of phosphatidylinositol-4-OH kinase

被引：217

作者：

Hendricks, KB ^{[1
]}

Wang, BQ ^{[1
]}

Schnieders, EA ^{[1
]}

Thorner, J ^{[1
]}

机构：

[1] Univ Calif Berkeley, Dept Mol & Cell Biol, Div Biochem & Mol Biol, Berkeley, CA 94720 USA

来源：

NATURE CELL BIOLOGY | 1999年 / 1卷 / 04期

关键词：

D O I：

10.1038/12058

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

In metazoans, certain calmodulin-related calcium-binding proteins (recoverins, neurocalcins and frequenins) are found at highest levels in excitable cells, but their physiological roles are largely uncharacterized. Here we show that Saccharomyces cerevisiae contains a frequenin homologue, Frq1, and that its target is Pik1, a phosphatidylinositol-4-OH kinase. Frq1 binds to a conserved sequence motif in Pik1 outside Pik1's catalytic domain and stimulates its activity in vitro. N-myristoylated Frq1 may also assist in Pik1 localization.

引用

页码：234 / 241

页数：8

共 55 条

[21]

HENDRICKS KB, 1999, THESIS U CALIFORNIA

[22] YEAST ESCHERICHIA-COLI SHUTTLE VECTORS WITH MULTIPLE UNIQUE RESTRICTION SITES [J].

HILL, JE ;

MYERS, AM ;

KOERNER, TJ ;

TZAGOLOFF, A .

YEAST, 1986, 2 (03) :163-167

[23] A 10-MINUTE DNA PREPARATION FROM YEAST EFFICIENTLY RELEASES AUTONOMOUS PLASMIDS FOR TRANSFORMATION OF ESCHERICHIA-COLI [J].

HOFFMAN, CS ;

WINSTON, F .

GENE, 1987, 57 (2-3) :267-272

[24] Calcium binding and conformational response in EF-hand proteins [J].

Ikura, M .

TRENDS IN BIOCHEMICAL SCIENCES, 1996, 21 (01) :14-17

[25] The nucleotide sequence of Saccharomyces cerevisiae chromosome IV [J].

Jacq C. ;

Alt-Mörbe J. ;

Andre B. ;

Arnold W. ;

Bahr A. ;

Ballesta J.P.G. ;

Bargues M. ;

Baron L. ;

Becker A. ;

Biteau N. ;

Blöcker H. ;

Blugeon C. ;

Boskovic J. ;

Brandt P. ;

Brückner M. ;

Buitrago M.J. ;

Coster F. ;

Delaveau T. ;

Del Rey F. ;

Dujon B. ;

Eide L.G. ;

Garcia-Cantalejo J.M. ;

Goffeau A. ;

Gomez-Peris A. ;

Granotier C. ;

Hanemann V. ;

Hankeln T. ;

Hoheisel J.D. ;

Jäger W. ;

Jimenez A. ;

Jonniaux J.-L. ;

Krämer C. ;

Küster H. ;

Laamanen P. ;

Legros Y. ;

Louis E. ;

Möller-Rieker S. ;

Monnet A. ;

Moro M. ;

Müller-Auer S. ;

Nußbaumer B. ;

Paricio N. ;

Paulin L. ;

Perea J. ;

Perez-Alonso M. ;

Perez-Ortin J.E. ;

Pohl T.M. ;

Prydz H. ;

Purnelle B. ;

Rasmussen S.W. .

Nature, 1997, 387 (Suppl 6632) :75-78

[26] The cytoskeleton and cell signaling: Component localization and mechanical coupling [J].

Janmey, PA .

PHYSIOLOGICAL REVIEWS, 1998, 78 (03) :763-781

[27] GENETIC AND BIOCHEMICAL-STUDIES OF PROTEIN N-MYRISTOYLATION [J].

JOHNSON, DR ;

BHATNAGAR, RS ;

KNOLL, LJ ;

GORDON, JI .

ANNUAL REVIEW OF BIOCHEMISTRY, 1994, 63 :869-914

[28] SEQUENCES THAT REGULATE THE DIVERGENT GAL1-GAL10 PROMOTER IN SACCHAROMYCES-CEREVISIAE [J].

JOHNSTON, M ;

DAVIS, RW .

MOLECULAR AND CELLULAR BIOLOGY, 1984, 4 (08) :1440-1448

[29] YEAST SACCHAROMYCES-CEREVISIAE SELECTABLE MARKERS IN PUC18 POLYLINKERS [J].

JONES, JS ;

PRAKASH, L .

YEAST, 1990, 6 (05) :363-366

[30] Phosphatidylinositol-4,5-bisphosphate is required for endocytic coated vesicle formation [J].

Jost, M ;

Simpson, F ;

Kavran, JM ;

Lemmon, MA ;

Schmid, SL .

CURRENT BIOLOGY, 1998, 8 (25) :1399-1402

← 1 2 3 4 5 6 →