Yeast homologue of neuronal frequenin is a regulator of phosphatidylinositol-4-OH kinase

被引：217

作者：

Hendricks, KB ^{[1
]}

Wang, BQ ^{[1
]}

Schnieders, EA ^{[1
]}

Thorner, J ^{[1
]}

机构：

[1] Univ Calif Berkeley, Dept Mol & Cell Biol, Div Biochem & Mol Biol, Berkeley, CA 94720 USA

来源：

NATURE CELL BIOLOGY | 1999年 / 1卷 / 04期

关键词：

D O I：

10.1038/12058

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

In metazoans, certain calmodulin-related calcium-binding proteins (recoverins, neurocalcins and frequenins) are found at highest levels in excitable cells, but their physiological roles are largely uncharacterized. Here we show that Saccharomyces cerevisiae contains a frequenin homologue, Frq1, and that its target is Pik1, a phosphatidylinositol-4-OH kinase. Frq1 binds to a conserved sequence motif in Pik1 outside Pik1's catalytic domain and stimulates its activity in vitro. N-myristoylated Frq1 may also assist in Pik1 localization.

引用

页码：234 / 241

页数：8

共 55 条

[1] Molecular mechanics of calcium-myristoyl switches [J].

Ames, JB ;

Ishima, R ;

Tanaka, T ;

Gordon, JI ;

Stryer, L ;

Ikura, M .

NATURE, 1997, 389 (6647) :198-202

[2] MOT1, A GLOBAL REPRESSOR OF RNA-POLYMERASE-II TRANSCRIPTION, INHIBITS TBP BINDING TO DNA BY AN ATP-DEPENDENT MECHANISM [J].

AUBLE, DT ;

HANSEN, KE ;

MUELLER, CGF ;

LANE, WS ;

THORNER, J ;

HAHN, S .

GENES & DEVELOPMENT, 1994, 8 (16) :1920-1934

[3] YEAST GENE REQUIRED FOR SPINDLE POLE BODY DUPLICATION - HOMOLOGY OF ITS PRODUCT WITH CA-2+-BINDING PROTEINS [J].

BAUM, P ;

FURLONG, C ;

BYERS, B .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1986, 83 (15) :5512-5516

[4] NOVEL FK506-BINDING AND RAPAMYCIN-BINDING PROTEIN (FPR3 GENE-PRODUCT) IN THE YEAST SACCHAROMYCES-CEREVISIAE IS A PROLINE ROTAMASE LOCALIZED TO THE NUCLEOLUS [J].

BENTON, BM ;

ZANG, JH ;

THORNER, J .

JOURNAL OF CELL BIOLOGY, 1994, 127 (03) :623-639

[5] SIGNAL-MEDIATED IMPORT OF BACTERIOPHAGE-T7 RNA-POLYMERASE INTO THE SACCHAROMYCES-CEREVISIAE NUCLEUS AND SPECIFIC TRANSCRIPTION OF TARGET GENES [J].

BENTON, BM ;

ENG, WK ;

DUNN, JJ ;

STUDIER, FW ;

STERNGLANZ, R ;

FISHER, PA .

MOLECULAR AND CELLULAR BIOLOGY, 1990, 10 (01) :353-360

[6] Ca2+-dependent regulation in neuronal gene expression [J].

Bito, H ;

Deisseroth, K ;

Tsien, RW .

CURRENT OPINION IN NEUROBIOLOGY, 1997, 7 (03) :419-429

[7] REGULATORY SUBUNIT (CNB1 GENE-PRODUCT) OF YEAST CA2+/CALMODULIN-DEPENDENT PHOSPHOPROTEIN PHOSPHATASES IS REQUIRED FOR ADAPTATION TO PHEROMONE [J].

CYERT, MS ;

THORNER, J .

MOLECULAR AND CELLULAR BIOLOGY, 1992, 12 (08) :3460-3469

[8] A TEMPERATURE-SENSITIVE CALMODULIN MUTANT LOSES VIABILITY DURING MITOSIS [J].

DAVIS, TN .

JOURNAL OF CELL BIOLOGY, 1992, 118 (03) :607-617

[9] ISOLATION OF THE YEAST CALMODULIN GENE - CALMODULIN IS AN ESSENTIAL PROTEIN [J].

DAVIS, TN ;

URDEA, MS ;

MASIARZ, FR ;

THORNER, J .

CELL, 1986, 47 (03) :423-431

[10] The mechanisms of vertebrate light adaptation: Speeded recovery versus slowed activation [J].

Detwiler, PB ;

GrayKeller, MP .

CURRENT OPINION IN NEUROBIOLOGY, 1996, 6 (04) :440-444

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