Viral Subversion of the Nuclear Pore Complex

被引：63
|
作者：
Le Sage, Valerie [1 ,2 ]
Mouland, Andrew J. [1 ,2 ]
机构：
[1] McGill Univ, Jewish Gen Hosp, Lady Davis Inst, Montreal, PQ H3T 1E2, Canada
[2] McGill Univ, Dept Med, Montreal, PQ H3A 2B4, Canada
来源：
VIRUSES-BASEL | 2013年 / 5卷 / 08期
基金：
加拿大健康研究院;
关键词：
viruses; nuclear pore complex; nucleoporins; nucleocytoplasmic transport; VESICULAR STOMATITIS-VIRUS; HEPATITIS-B-VIRUS; POLIOVIRUS-INFECTED CELLS; MESSENGER-RNA EXPORT; C-TERMINAL DOMAIN; INFLUENZA-VIRUS; NUCLEOPORIN NUP153; NUCLEOCYTOPLASMIC TRANSPORT; HIV-1; INTEGRASE; GENE-EXPRESSION;
D O I：
10.3390/v5082019
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
The nuclear pore complex (NPC) acts as a selective barrier between the nucleus and the cytoplasm and is responsible for mediating communication by regulating the transport of RNA and proteins. Numerous viral pathogens have evolved different mechanisms to hijack the NPC in order to regulate trafficking of viral proteins, genomes and even capsids into and out of the nucleus thus promoting virus replication. The present review examines the different strategies and the specific nucleoporins utilized during viral infections as a means of promoting their life cycle and inhibiting host viral defenses.
引用
收藏
页码：2019 / 2042
页数：24
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