Viral Subversion of the Nuclear Pore Complex

被引：63
|
作者：
Le Sage, Valerie [1 ,2 ]
Mouland, Andrew J. [1 ,2 ]
机构：
[1] McGill Univ, Jewish Gen Hosp, Lady Davis Inst, Montreal, PQ H3T 1E2, Canada
[2] McGill Univ, Dept Med, Montreal, PQ H3A 2B4, Canada
来源：
VIRUSES-BASEL | 2013年 / 5卷 / 08期
基金：
加拿大健康研究院;
关键词：
viruses; nuclear pore complex; nucleoporins; nucleocytoplasmic transport; VESICULAR STOMATITIS-VIRUS; HEPATITIS-B-VIRUS; POLIOVIRUS-INFECTED CELLS; MESSENGER-RNA EXPORT; C-TERMINAL DOMAIN; INFLUENZA-VIRUS; NUCLEOPORIN NUP153; NUCLEOCYTOPLASMIC TRANSPORT; HIV-1; INTEGRASE; GENE-EXPRESSION;
D O I：
10.3390/v5082019
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
The nuclear pore complex (NPC) acts as a selective barrier between the nucleus and the cytoplasm and is responsible for mediating communication by regulating the transport of RNA and proteins. Numerous viral pathogens have evolved different mechanisms to hijack the NPC in order to regulate trafficking of viral proteins, genomes and even capsids into and out of the nucleus thus promoting virus replication. The present review examines the different strategies and the specific nucleoporins utilized during viral infections as a means of promoting their life cycle and inhibiting host viral defenses.
引用
收藏
页码：2019 / 2042
页数：24
相关论文
共 50 条
  • [1] Specific Cleavage of the Nuclear Pore Complex Protein Nup62 by a Viral Protease
    Park, Nogi
    Skern, Tim
    Gustin, Kurt E.
    JOURNAL OF BIOLOGICAL CHEMISTRY, 2010, 285 (37) : 28796 - 28805
  • [2] Cancer and the Nuclear Pore Complex
    Simon, Dan N.
    Rout, Michael P.
    CANCER BIOLOGY AND THE NUCLEAR ENVELOPE: RECENT ADVANCES MAY ELUCIDATE PAST PARADOXES, 2014, 773 : 285 - 307
  • [3] Effect of Viral Infection on the Nuclear Envelope and Nuclear Pore Complex
    Cohen, Sarah
    Etingov, Igor
    Pante, Nelly
    INTERNATIONAL REVIEW OF CELL AND MOLECULAR BIOLOGY, VOL 299, 2012, 299 : 117 - 159
  • [4] The role of nuclear pore complex in tumor microenvironment and metastasis
    Funasaka, Tatsuyoshi
    Wong, Richard W.
    CANCER AND METASTASIS REVIEWS, 2011, 30 (02) : 239 - 251
  • [5] The Structure of the Nuclear Pore Complex (An Update)
    Lin, Daniel H.
    Hoelz, Andre
    ANNUAL REVIEW OF BIOCHEMISTRY, VOL 88, 2019, 88 : 725 - 783
  • [6] Insights into the gate of the nuclear pore complex
    Zwerger, Monika
    Eibauer, Matthias
    Medalia, Ohad
    NUCLEUS, 2016, 7 (01) : 1 - 7
  • [7] The Quest for the Blueprint of the Nuclear Pore Complex
    Glavy, Joseph S.
    PROTEIN JOURNAL, 2019, 38 (04) : 363 - 376
  • [8] The Nuclear Pore Complex and Nuclear Transport
    Wente, Susan R.
    Rout, Michael P.
    COLD SPRING HARBOR PERSPECTIVES IN BIOLOGY, 2010, 2 (10): : a000562
  • [9] Viral Subversion of Nucleocytoplasmic Trafficking
    Yarbrough, Melanie L.
    Mata, Miguel A.
    Sakthivel, Ramanavelan
    Fontoura, Beatriz M. A.
    TRAFFIC, 2014, 15 (02) : 127 - 140
  • [10] The Nuclear Pore Complex Is a Key Target of Viral Proteases to Promote Viral Replication
    Adrian De Jesus-Gonzalez, Luis
    Palacios-Rapalo, Selvin
    Manuel Reyes-Ruiz, Jose
    Fidel Osuna-Ramos, Juan
    Daniel Cordero-Rivera, Carlos
    Noe Farfan-Morales, Carlos
    Lorena Gutierrez-Escolano, Ana
    Maria del Angel, Rosa
    VIRUSES-BASEL, 2021, 13 (04):
12345