A Triggered DNA Hydrogel Cover to Envelop and Release Single Cells

被引：143

作者：

Jin, Juan ^{[1
,2
,3
]}

Xing, Yongzheng ^{[1
]}

Xi, Yanli ^{[4
]}

Liu, Xueli ^{[4
]}

Zhou, Tao ^{[1
]}

Ma, Xinxin ^{[1
]}

Yang, Zhongqiang ^{[1
]}

Wang, Shutao ^{[4
]}

Liu, Dongsheng ^{[1
]}

机构：

[1] Tsinghua Univ, Dept Chem, Minist Educ, Key Lab Organ Optoelect & Mol Engn, Beijing 100084, Peoples R China

[2] Natl Ctr Nanosci & Technol, Beijing 100190, Peoples R China

[3] Univ Chinese Acad Sci, Beijing 100049, Peoples R China

[4] Chinese Acad Sci, BNLMS, Key Lab Organ Solids, Inst Chem, Beijing 100190, Peoples R China

来源：

ADVANCED MATERIALS | 2013年 / 25卷 / 34期

基金：

中国国家自然科学基金;

关键词：

DNA hydrogel; envelop and release; permeable; responsiveness; single cell; CROSS-LINKED HYDROGEL; EFFICIENT CAPTURE; APTAMER; ARRAYS;

D O I：

10.1002/adma.201301175

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

We develop an enzyme-triggered permeable DNA hydrogel cover to envelop and release single cells in microwells. The porous structure of the DNA hydrogel allows nutrients and waste to pass through, leading to a cell viability as high as 98%. The design provides a general method to culture, monitor, and manipulate single cells, and has potential applications in cell patterning and studying cell communication. Copyright © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

引用

页码：4714 / 4717

页数：4

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