A new class of selective and potent inhibitors of neuronal nitric oxide synthase

被引：21

作者：

Lowe, JA ^{[1
]}

Qian, WM

Volkmann, RA

Heck, S

Nowakowski, J

Nelson, R

Nolan, C

Liston, D

Ward, K

Zorn, S

Johnson, C

Vanase, M

Faraci, WS

Verdries, KA

Baxter, J

Doran, S

Sanders, M

Ashton, M

Whittle, P

Stefaniak, M

机构：

[1] Pfizer Inc, Div Cent Res, Groton, CT 06340 USA

[2] Pfizer Inc, Div Cent Res, Sandwich, Kent, England

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1999年 / 9卷 / 17期

关键词：

D O I：

10.1016/S0960-894X(99)00432-1

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The synthesis and SAR of a series of 6-(4-(substituted)phenyl)-2-aminopyridines as inhibitors of nitric oxide synthase are described. Compound 3a from this series shows potent and selective inhibition of the human nNOS isoform, with pharmacokinetics sufficient to provide in vivo inhibition of nNOS activity. (C) 1999 Elsevier Science Ltd. All rights reserved.

引用

页码：2569 / 2572

页数：4

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