Comparative inhibitory properties of some Indian medicinal plant extracts against photosensitization-induced lipid damage
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作者:
Bhattacharya, Sayanti
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Dr BC Roy Postgrad Inst Basic Med Sci, Dept Biochem, Kolkata 700020, IndiaBhabha Atom Res Ctr, Div Bioorgan, Bombay 400085, Maharashtra, India
Bhattacharya, Sayanti
[2
]
Kaniat, Jaya P.
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Bhabha Atom Res Ctr, Radiat Biol & Hlth Sci Div, Bombay 400085, Maharashtra, IndiaBhabha Atom Res Ctr, Div Bioorgan, Bombay 400085, Maharashtra, India
Kaniat, Jaya P.
[3
]
Bandyopadhyay, Sandip K.
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Dr BC Roy Postgrad Inst Basic Med Sci, Dept Biochem, Kolkata 700020, IndiaBhabha Atom Res Ctr, Div Bioorgan, Bombay 400085, Maharashtra, India
Bandyopadhyay, Sandip K.
[2
]
Chattopadhyay, Subrata
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Bhabha Atom Res Ctr, Div Bioorgan, Bombay 400085, Maharashtra, India
Bhabha Atom Res Ctr, Radiat Biol & Hlth Sci Div, Bombay 400085, Maharashtra, IndiaBhabha Atom Res Ctr, Div Bioorgan, Bombay 400085, Maharashtra, India
Chattopadhyay, Subrata
[1
,3
]
机构:
[1] Bhabha Atom Res Ctr, Div Bioorgan, Bombay 400085, Maharashtra, India
[2] Dr BC Roy Postgrad Inst Basic Med Sci, Dept Biochem, Kolkata 700020, India
[3] Bhabha Atom Res Ctr, Radiat Biol & Hlth Sci Div, Bombay 400085, Maharashtra, India
The protective activities of Emblica of officinalis, Terminalia bellerica and Terminalia chebula ethanol extracts against photosensitization-induced oxidation of rat liver mitochondrial lipid were assessed. All the extracts Could effectively prevent lipid peroxidation, as assessed by measuring thiobarbituric acid-reactive Substrates, lipid hydroperoxide, conjugated diene and 4-hydroxynonenal. The E. officinalis extract was the most potent, revealing its superior ability to scavenge O-1(2). The extracts also afforded excellent protection against iron-mediated lipid peroxidation that might also be useful in reducing photo-induced iron toxicity. The activities of the extracts were primarily due to their constituent phenolics. (C) 2008 Elsevier Ltd. All rights reserved.