Detection of DNA fragments encompassing the deletion junction of mitochondrial genome

被引：10

作者：

Goto, YI ^{[1
]}

Nishino, I ^{[1
]}

Horai, S ^{[1
]}

Nonaka, I ^{[1
]}

机构：

[1] NATL INST GENET,DEPT HUMAN GENET,MISHIMA,SHIZUOKA 411,JAPAN

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1996年 / 222卷 / 02期

关键词：

D O I：

10.1006/bbrc.1996.0724

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Deletions and occasional duplications in mitochondrial DNA have been known to be present in mitochondrial diseases and in aged tissues. The junctional sequences of the rearrangements must be determined for detecting duplication, but its procedures seem laborious for routine examination. The joint method of long polymerase chain reaction plus digestion by three restriction enzymes provides a simple method to detect and map the deletion sites of mitochondrial DNA. (C) 1996 Academic Press, Inc.

引用

页码：215 / 219

页数：5

共 10 条

[1] SEQUENCE AND ORGANIZATION OF THE HUMAN MITOCHONDRIAL GENOME [J].

ANDERSON, S ;

BANKIER, AT ;

BARRELL, BG ;

DEBRUIJN, MHL ;

COULSON, AR ;

DROUIN, J ;

EPERON, IC ;

NIERLICH, DP ;

ROE, BA ;

SANGER, F ;

SCHREIER, PH ;

SMITH, AJH ;

STADEN, R ;

YOUNG, IG .

NATURE, 1981, 290 (5806) :457-465

[2] CHRONIC PROGRESSIVE EXTERNAL OPHTHALMOPLEGIA - A CORRELATIVE STUDY OF MITOCHONDRIAL-DNA DELETIONS AND THEIR PHENOTYPIC-EXPRESSION IN MUSCLE BIOPSIES [J].

GOTO, Y ;

KOGA, Y ;

HORAI, S ;

NONAKA, I .

JOURNAL OF THE NEUROLOGICAL SCIENCES, 1990, 100 (1-2) :63-69

[3] DELETIONS OF MUSCLE MITOCHONDRIAL-DNA IN PATIENTS WITH MITOCHONDRIAL MYOPATHIES [J].

HOLT, IJ ;

HARDING, AE ;

MORGANHUGHES, JA .

NATURE, 1988, 331 (6158) :717-719

[4] MITOCHONDRIAL-DNA POLYMORPHISM IN JAPANESE .1. ANALYSIS WITH RESTRICTION ENZYMES OF 6 BASE PAIR RECOGNITION [J].

HORAI, S ;

GOJOBORI, T ;

MATSUNAGA, E .

HUMAN GENETICS, 1984, 68 (04) :324-332

[5] FAMILIES OF MTDNA REARRANGEMENTS CAN BE DETECTED IN PATIENTS WITH MTDNA DELETIONS - DUPLICATIONS MAY BE A TRANSIENT INTERMEDIATE FORM [J].

POULTON, J ;

DEADMAN, ME ;

BINDOFF, L ;

MORTEN, K ;

LAND, J ;

BROWN, G .

HUMAN MOLECULAR GENETICS, 1993, 2 (01) :23-30

[6] PEARSON MARROW PANCREAS SYNDROME - A MULTISYSTEM MITOCHONDRIAL DISORDER IN INFANCY [J].

ROTIG, A ;

CORMIER, V ;

BLANCHE, S ;

BONNEFONT, JP ;

LEDEIST, F ;

ROMERO, N ;

SCHMITZ, J ;

RUSTIN, P ;

FISCHER, A ;

SAUDUBRAY, JM ;

MUNNICH, A .

JOURNAL OF CLINICAL INVESTIGATION, 1990, 86 (05) :1601-1608

[7] SPECTRUM OF MITOCHONDRIAL-DNA REARRANGEMENTS IN THE PEARSON MARROW-PANCREAS SYNDROME [J].

ROTIG, A ;

BOURGERON, T ;

CHRETIEN, D ;

RUSTIN, P ;

MUNNICH, A .

HUMAN MOLECULAR GENETICS, 1995, 4 (08) :1327-1330

[8] OXIDATIVE DAMAGE AND MITOCHONDRIAL DECAY IN AGING [J].

SHIGENAGA, MK ;

HAGEN, TM ;

AMES, BN .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1994, 91 (23) :10771-10778

[9]

XI C, 1995, AM J HUM GENET, V57, P239

[10]

ZEVIANI M, 1988, NEUROLOGY, V38, P1339

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