N-tert-butoxycarbonyl (BOC) deprotection using boron trifluoride etherate

被引：52
|
作者：
Evans, EF
Lewis, NJ
Kapfer, I
Macdonald, G
Taylor, RJK
机构：
[1] UNIV YORK,DEPT CHEM,YORK YO1 5DD,N YORKSHIRE,ENGLAND
[2] SMITHKLINE BEECHAM PHARMACEUT,TONBRIDGE TN11 9AN,KENT,ENGLAND
来源：
SYNTHETIC COMMUNICATIONS | 1997年 / 27卷 / 11期
基金：
英国工程与自然科学研究理事会;
关键词：
D O I：
10.1080/00397919708006783
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A mild and efficient procedure is described for the removal of the tert-butoxycarbonyl (BOG) group using boron trifluoride etherate and molecular sieves in dichloromethane at room temperature. The scope of this procedure is explored for the deprotection of a variety of amines including amino acid derivatives.
引用
收藏
页码：1819 / 1825
页数：7
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