Multi-photon excitation in uncaging the small molecule bioregulator nitric oxide

被引:28
作者
Garcia, John V. [1 ]
Zhang, Fan [2 ,3 ]
Ford, Peter C. [1 ]
机构
[1] Univ Calif Santa Barbara, Dept Chem & Biochem, Santa Barbara, CA 93106 USA
[2] Fudan Univ, Dept Chem, Shanghai Key Lab Mol Catalysis, Shanghai 200433, Peoples R China
[3] Fudan Univ, Lab Innovat & Adv Mat, Shanghai 200433, Peoples R China
来源
PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY A-MATHEMATICAL PHYSICAL AND ENGINEERING SCIENCES | 2013年 / 371卷 / 1995期
基金
美国国家科学基金会;
关键词
nitric oxide; two-photon excitation; upconversion nanoparticles; photochemistry; COOPERATIVE UP-CONVERSION; NEAR-INFRARED LIGHT; ROUSSINS RED SALT; 2-PHOTON ABSORPTION; SINGLE-PHOTON; QUANTUM DOTS; FLUORESCENT NANOPARTICLES; PHOTOCHEMICAL PRODUCTION; PHOTODYNAMIC THERAPY; RUTHENIUM NITROSYLS;
D O I
10.1098/rsta.2012.0129
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
Multi-photon excitation allows one to use tissue transmitting near-infrared (NIR) light to access excited states with energies corresponding to single-photon excitation in the visible or ultraviolet wavelength ranges. Here, we present an overview of the application of both simultaneous and sequential multi-photon excitation in studies directed towards the photochemical delivery ('uncaging') of bioactive small molecules such as nitric oxide (NO) to physiological targets. Particular focus will be directed towards the use of dyes with high two-photon absorption cross sections and lanthanide ion-doped upconverting nanoparticles as sensitizers to facilitate the uncaging of NO using NIR excitation.
引用
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页数:25
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