Vitamin D levels in Malawian infants from birth to 24 months

被引：16

作者：

Amukele, Timothy K. ^{[1
]}

Soko, Dean ^{[2
]}

Katundu, Pauline ^{[2
]}

Kamanga, Melvin ^{[2
]}

Sun, Jin ^{[3
]}

Kumwenda, Newton I. ^{[3
]}

Taha, Taha E. ^{[3
]}

机构：

[1] Johns Hopkins Univ, Sch Med, Dept Pathol, Baltimore, MD 21205 USA

[2] Johns Hopkins Univ, Res Project, Blantyre, Malawi

[3] Johns Hopkins Univ, Bloomberg Sch Publ Hlth, Dept Epidemiol, Baltimore, MD USA

来源：

ARCHIVES OF DISEASE IN CHILDHOOD | 2013年 / 98卷 / 03期

关键词：

D SUPPLEMENTATION; D DEFICIENCY; 25-HYDROXYVITAMIN D; SERUM; PREGNANCY; RISK; CHILDHOOD; CALCIUM; MOTHER; HEALTH;

D O I：

10.1136/archdischild-2012-302377

中图分类号：

R72 [儿科学];

学科分类号：

100202 ;

摘要：

We measured longitudinal levels of vitamin D in unsupplemented Malawian infants at 0 (birth), 2, 12, 15, 18 and 24 months of age. Matched maternal plasma and breast milk vitamin D-2 and D-3 levels were also measured at delivery and 2 months postpartum. Vitamin D was measured using isotope-dilution liquid chromatography tandem-mass spectrometry. Vitamin D-3 levels in children were 36% of adult levels at birth, 60% of adult levels at age 2 months, and at par with adult levels by 12 months of age. This adult-equivalent level is subsequently maintained through age 24 months and consisted of a 98% molar ratio of vitamin D-3. Vitamin D levels in breast milk were below the limit of detection, 0.1 ng/ml. Breast milk of unsupplemented Malawian mothers is a poor source of vitamin D.

引用

页码：180 / 183

页数：4

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