Increased number of FoxP3+CD4+ regulatory T cells in inflammatory bowel disease

被引：25

作者：

Ban, Hiromitsu ^{[1
]}

Andoh, Akira ^{[1
]}

Shioya, Makoto ^{[1
]}

Nishida, Atsushi ^{[1
]}

Tsujikawa, Tomoyuki ^{[1
]}

Fujiyama, Yoshihide ^{[1
]}

机构：

[1] Shiga Univ Med Sci, Dept Med, Otsu, Shiga 5202192, Japan

来源：

MOLECULAR MEDICINE REPORTS | 2008年 / 1卷 / 05期

关键词：

CD4(+) regulatory T cells; inflammatory bowel disease;

D O I：

10.3892/mmr_00000006

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

FoxP3 is a member of the forkheadlwinged helix family of transcription factors and plays a critical role in the development and function of CD4(+)CD25(+) regulatory T cells (Tregs). In this study, we performed an immunohistochemical evaluation of FoxP3-expressing cells in inflammatory bowel disease (IBD) mucosa. Mucosal FoxP3 expression was evaluated by immunohistochemistry in samples from normal (n=30), ulcerative colitis (UC) (n=53) and Crohn's disease (CD) (n=24) mucosa. There were no FoxP3-immunopositive cells in the normal colonic mucosa. In contrast, FoxP3-immunopositive cells were significantly increased in the inflamed regions of patients with active UC and CD. FoxP3-immunopositive cells completely coincided with some of the CD4-positive T cells. In conclusion, FoxP3-immunopositive Tregs were expanded in the inflamed mucosa of IBD patients. This suggests that these cells have impaired regulatory functions in the IBD mucosa.

引用

页码：647 / 650

页数：4

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