Tumor Microenvironment Stimuli-Responsive Fluorescence Imaging and Synergistic Cancer Therapy by Carbon-Dot-Cu2+Nanoassemblies

被引:360
作者
Sun, Shan [1 ,2 ]
Chen, Qiao [1 ,2 ]
Tang, Zhongdi [1 ,2 ]
Liu, Chuang [1 ,2 ]
Li, Zhongjun [3 ]
Wu, Aiguo [1 ,2 ]
Lin, Hengwei [1 ,2 ]
机构
[1] Chinese Acad Sci, Cixi Inst Biomed Engn, Key Lab Magnet Mat & Devices, 1219 ZhongGuan West Rd, Ningbo 315201, Peoples R China
[2] Chinese Acad Sci, Zhejiang Engn Res Ctr Biomed Mat, Ningbo Inst Mat Technol & Engn, 1219 ZhongGuan West Rd, Ningbo 315201, Peoples R China
[3] Zhengzhou Univ, Coll Chem & Mol Engn, Zhengzhou 450001, Peoples R China
基金
中国国家自然科学基金;
关键词
carbon dots; nanoassemblies; stimulus-response; synergistic cancer treatment; tumor microenvironment; CARBON DOTS; QUANTUM DOTS; OXIDATION; EFFICIENT;
D O I
10.1002/anie.202007786
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
A method is developed to fabricate tumor microenvironment (TME) stimuli-responsive nanoplatform for fluorescence (FL) imaging and synergistic cancer therapy via assembling photosensitizer (chlorine e6, Ce6) modified carbon dots (CDs-Ce6) and Cu2+. The as-obtained nanoassemblies (named Cu/CC nanoparticles, NPs) exhibit quenched FL and photosensitization due to the aggregation of CDs-Ce6. Their FL imaging and photodynamic therapy (PDT) functions are recovered efficiently once they entering tumor sites by the stimulation of TME. Introducing of Cu(2+)not only provides extra chemodynamic therapy (CDT) function through reaction with hydrogen peroxide (H2O2), but also depletes GSH in tumors by a redox reaction, thus amplifying the intracellular oxidative stress and enhancing the efficacy of reactive oxygen species (ROS) based therapy. Cu/CC NPs can act as a FL imaging guided trimodal synergistic cancer treatment agent by photothermal therapy (PTT), PDT, and thermally amplified CDT.
引用
收藏
页码:21041 / 21048
页数:8
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