Reactions of regioisomeric 3,3-dimethyl- and 2,2-dimethyl-6-trifluoromethyl-2,3-dihydro-4-pyrones with N-nucleophiles

被引：6

作者：

Sosnovskikh, VY ^{[1
]}

Mel'nikov, MY ^{[1
]}

机构：

[1] AM Gorky Ural State Univ, Ekaterinburg 620083, Russia

来源：

RUSSIAN CHEMICAL BULLETIN | 1999年 / 48卷 / 05期

基金：

俄罗斯基础研究基金会;

关键词：

substituted 2,3-dihydro-4-pyrones; substituted tetrahydro-4-pyrones; CF3-containing aminoenones; pyrazoles; Delta(2)-isoxazolines;

D O I：

10.1007/BF02494648

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Reactions of 2,2-dimethyl-6-trifluoromethyl-2,3-dihydro-4-pyrone with ethylenediamine, hydrazine, or hydroxylamine yield 5-methyl-7-trifluoromethyl-2,3-dihydro-1H-1,4-diazepine, 3(5)-(2-hydroxy-2-methylpropyl)-5(3)-trifluoromethylpyrazole, and 5-hydroxy-3-(2-hydroxy-2-methylpropyl)-5-trifluoromtthyl-Delta(2)-isoxazoline, respectively. The same compounds were obtained from 2-amino-1,1,1-trifluoro-6-hydroxy-6-methylhept-2(Z)-en-4-one and 2-hydroxy-6,6-dimethyl-2-trifluoromethyltetrahydro-4-pyrone.

引用

页码：975 / 978

页数：4

共 12 条

[1]

PASHKEVICH KI, 1981, USP KHIM+, V50, P325

[2]

PASHKEVICH KI, 1981, B ACAD SCI USSR DIV, V30

[3]

PROKOFEV EP, 1979, B ACAD SCI USSR DIV, V28

[4] A simple synthesis of 4-amino-6-methyl-1,1,1-trifluoro(trichloro)hepta-3,5-dien-2-ones and 2,2-dimethyl-6-trifluoromethyl-2,3-dihydro-4-pyridone [J].

Sosnovskikh, VY .

RUSSIAN CHEMICAL BULLETIN, 1997, 46 (12) :2145-2146

[5] Interactions of aliphatic β-amino-β-trifluoromethylvinyl ketones with ethylenediamine [J].

Sosnovskikh, VY ;

Mel'nikov, MY ;

Kovaleva, IA .

RUSSIAN CHEMICAL BULLETIN, 1998, 47 (11) :2234-2237

[6] Synthesis and reactions of 2-hydroxy-5,5-dimethyl- and 2-hydroxy-5,5-pentamethylene-2-trifluoromethyltetrahydro-4-pyranones with N-nucleophiles [J].

Sosnovskikh, VY ;

Mel'nikov, MY ;

Zaitsev, AV ;

Bogdanov, EA .

RUSSIAN CHEMICAL BULLETIN, 1998, 47 (06) :1170-1174

[7]

Sosnovskikh VY, 1998, ZH ORG KHIM+, V34, P303

[8]

Sosnovskikh VY, 1998, MENDELEEV COMMUN, P198

[9] Reaction of 3,3-dialkyl-6-trifluoromethyl-2,3-dihydro-4-pyrones with hydrazine hydrate [J].

Sosnovskikh, VY ;

Mel'nikov, MY ;

Kodess, MI .

RUSSIAN CHEMICAL BULLETIN, 1998, 47 (07) :1365-1368

[10]

SOSNOVSKIKH VY, 1993, RUSS J ORG CHEM+, V29, P74

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