Determinants of plasma concentrations of perfluoroalkyl substances in pregnant Norwegian women

被引：166

作者：

Brantsaeter, A. L. ^{[1
]}

Whitworth, K. W. ^{[2
]}

Ydersbond, T. A. ^{[3
]}

Haug, L. S. ^{[1
]}

Haugen, M. ^{[1
]}

Knutsen, H. K. ^{[1
]}

Thomsen, C. ^{[1
]}

Meltzer, H. M. ^{[1
]}

Becher, G. ^{[1
]}

Sabaredzovic, A. ^{[1
]}

Hoppin, J. A. ^{[4
]}

Eggesbo, M. ^{[5
]}

Longnecker, M. P. ^{[4
]}

机构：

[1] Norwegian Inst Publ Hlth, Div Environm Med, NO-0403 Oslo, Norway

[2] Univ Texas Hlth Sci Ctr Houston, Sch Publ Hlth, San Antonio, TX 78229 USA

[3] Stat Norway, N-0033 Oslo, Norway

[4] NIEHS, Epidemiol Branch, NIH, Dept Hlth & Human Serv, Res Triangle Pk, NC 27709 USA

[5] Norwegian Inst Publ Hlth, Div Epidemiol, NO-0403 Oslo, Norway

来源：

ENVIRONMENT INTERNATIONAL | 2013年 / 54卷

基金：

美国国家卫生研究院;

关键词：

Perfluoroalkyl substances; Reproductive history; Pregnancy; Dietary exposure; GLOMERULAR-FILTRATION-RATE; PERFLUORINATED COMPOUNDS; CHILD COHORT; PERFLUOROOCTANOATE PFOA; POLYFLUOROALKYL COMPOUNDS; MATERNAL CONCENTRATIONS; SERUM CONCENTRATIONS; PRENATAL EXPOSURE; DIETARY EXPOSURE; BIRTH-WEIGHT;

D O I：

10.1016/j.envint.2012.12.014

中图分类号：

X [环境科学、安全科学];

学科分类号：

08 ; 0830 ;

摘要：

Background: Perfluoroalkyl substances (PFASs) are widespread pollutants that have been associated with adverse health effects although not on a consistent basis. Diet has been considered the main source of exposure. The aim of the present study was to identify determinants of four plasma PFASs in pregnant Norwegian women. Methods: This study is based in the Norwegian Mother and Child Cohort Study (MoBa) conducted by the Norwegian Institute of Public Health. Our sample included 487 women who enrolled in MoBa from 2003 to 2004. A questionnaire regarding sociodemographic, medical, and reproductive history was completed at 17 weeks of gestation and a dietary questionnaire was completed at 22 weeks of gestation. Maternal plasma samples were obtained around 17 weeks of gestation. Plasma concentrations of four PFASs (perfluorooctane sulfonate (PFOS), perfluorooctanoate (PFOA), perfluorohexane sulfonate (PFHxS), and perfluorononanoate (PFNA)) were examined in relation to demographic, lifestyle, dietary, and pregnancy-related covariates. Predictors were identified by optimizing multiple linear regression models using Akaike's information criterion (AIC). Results: Parity was the determinant with the largest influence on plasma PFAS concentrations, with r(2) between 0.09 and 0.32 in simple regression models. In optimal multivariate models, when compared to nulliparous women, parous women had 46%, 70%, 19%, and 62% lower concentrations of PFOS, PFOA, PFHxS, and PFNA respectively (p<0.001 except for PFHxS, p<0.01). In all these models, duration of breastfeeding was associated with reduced PFAS levels. PFOA showed the largest reduction from breastfeeding, with a 2-3% reduction per month of breastfeeding in typical cases. Levels of PFOS, PFOA, and PFNA increased with time since most recent pregnancy. While pregnancy-related factors were the most important predictors, diet was a significant factor explaining up to 4% of the variance. One quartile increase in estimated dietary PFAS intake was associated with plasma PFOS, PFOA, PFHxS, and PFNA concentration increases of 72%, 33%, 5.8% and 9.8%, respectively, resulting in small, although non-trivial absolute changes in PFAS concentrations. Conclusion: Previous pregnancies and breastfeeding duration were the most important determinants of PFASs in this sample of pregnant women. (C) 2013 Elsevier Ltd. All rights reserved.

引用

页码：74 / 84

页数：11

共 60 条

[1] Pharmacokinetic modeling of saturable, renal resorption of perfluoroalkylacids in monkeys - Probing the determinants of long plasma half-lives [J].