Protein kinase C isozymes as therapeutic targets for treatment of human cancers

被引：32

作者：

Fields, Alan P. ^{[1
]}

Murray, Nicole R. ^{[1
]}

机构：

[1] Mayo Clin, Ctr Comprehens Canc, Dept Canc Biol, Jacksonville, FL 32224 USA

来源：

ADVANCES IN ENZYME REGULATION, VOL 48 | 2008年 / 48卷

关键词：

D O I：

10.1016/j.advenzreg.2007.11.014

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

PKC isozymes play specific, non-redundant functional roles in numerous cellular processes, including proliferation, differentiation, cellular invasion and apoptosis. We have determined that PKCβII and PKCι are both critical pro-carcinogenic genes involved in multiple human cancers. PKCι (PRKCI) is a bonafide human oncogene, the first PKC isozyme that can be so classified. Both PKCβII and PKCι are legitimate therapeutic targets to which novel targeted therapy has been successfully developed and is being evaluated clinically. © 2007 Elsevier Ltd. All rights reserved.

引用

页码：166 / 178

页数：13

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