Ruthenium-catalyzed asymmetric propargylic substitution reactions of propargylic alcohols with acetone

被引：126

作者：

Inada, Y

Nishibayashi, Y ^{[1
]}

Uemura, S

机构：

[1] Univ Tokyo, Inst Engn Innovat, Bunkyo Ku, Tokyo 1138656, Japan

[2] Kyoto Univ, Grad Sch Engn, Dept Energy & Hydrocarbon chem, Nishikyo Ku, Kyoto, Japan

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2005年 / 44卷 / 47期

关键词：

asymmetric catalysis; nucleophilic substitution; ruthenium; S ligands; synthetic methods;

D O I：

10.1002/anie.200502981

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Enantioselective propargylic substitution reactions of propargylic alcohols with acetone catalyzed by a diruthenium complex gives the propargylic alkylated products in good yields with up to 82% ee. A π-π interaction of phenyl rings between the ligand and allenylidene moieties is considered to play a crucial role in achieving such a high selectivity (see scheme; Cp*=pentamethylcyclopentadiene). (Chemical Equation Presented). © 2005 Wiley-VCH Verlag GmbH & Co. KGaA.

引用

页码：7715 / 7717

页数：3

共 26 条

[1] Synergistic dimetallic effects in propargylic substitution reaction catalyzed by thiolate-bridged diruthenium complex [J].