Association of angiotensin-converting enzyme I gene I/D polymorphism with endometrial but not with ovarian cancer

被引：15

作者：

Alves Correa-Noronha, Silvana Aparecida ^{[1
]}

Ribeiro de Noronha, Samuel Marcos ^{[1
]}

Alecrim, Cheryl ^{[1
]}

Mesquita, Adriana de Carvalho ^{[1
]}

da Silva Brito, Gabriela Soares ^{[1
]}

Junqueira, Michele Gilvana ^{[1
]}

Leite, Daniela Batista ^{[1
]}

de Carvalho, Cristina Valletta ^{[1
]}

Cotrim Guerreiro da Silva, Ismael Dale ^{[1
]}

机构：

[1] Univ Fed Sao Paulo, Dept Gynecol, Mol Gynecol Lab, BR-04039032 Sao Paulo, Brazil

来源：

GYNECOLOGICAL ENDOCRINOLOGY | 2012年 / 28卷 / 11期

基金：

巴西圣保罗研究基金会;

关键词：

Angiotensin converting enzyme; endometrial cancer; ovarian cancer; BREAST-CANCER; AT(1) RECEPTOR; AGONIST BINDING; TYPE-1; RECEPTOR; RELEVANT ROLE; HELIX-VI; RISK; ACE; INSERTION/DELETION; AMINOPEPTIDASE;

D O I：

10.3109/09513590.2012.683060

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Associations have been found between the angiotensin-converting enzyme insertion deletion (I/D) polymorphism (ACE I/D) and endometrial and epithelial ovarian cancer (EC and EOC, respectively). In this study, the following frequencies for each of three ACE polymorphisms, DD, ID, and II, respectively, were observed: in the EC group, 55, 24, and 21% versus the control group 39, 40, and 21% (p = 0.033*); in the EOC group 49, 36, and 15% versus the control group 49, 33, and 18% (p = 0.82). According to these allelic distributions, DD carriers are 2.0 times more likely than individuals carrying the ID or II genotypes to develop EC; therefore, the DD genotype seems to be protective against EC. In contrast, no association was observed between ACE (I/D) polymorphism with EOC. The ACE (I/D) polymorphism might play a role in the pathogenesis of EC and it should be considered when identifying genetic markers for EC.

引用

页码：889 / 891

页数：3

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