Responsive layer-by-layer materials for drug delivery

被引：179

作者：

Wohl, Benjamin M. ^{[1
]}

Engbersen, Johan F. J. ^{[1
]}

机构：

[1] Univ Twente, Fac Sci & Technol, MIRA Inst Biomed Technol & Tech Med, Dept Biomed Chem, NL-7500 AE Enschede, Netherlands

来源：

JOURNAL OF CONTROLLED RELEASE | 2012年 / 158卷 / 01期

关键词：

Layer-by-layer; LbL; Responsive polymers; Polyelectrolyte multilayers; Drug delivery; Triggered release; POLYELECTROLYTE MULTILAYER MICROCAPSULES; FUNCTIONAL CORE/SHELL NANOPARTICLES; POLYMER HYDROGEL CAPSULES; TUNABLE DNA RELEASE; PLASMID DNA; THIN-FILMS; IN-VITRO; NANOSTRUCTURED MATERIALS; SUCCESSIVE DEPOSITION; COPOLYMER MICELLES;

D O I：

10.1016/j.jconrel.2011.08.035

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Due to its versatility and ease of use the layer-by-layer (LbL) assembly technique has been under intensive investigation for drug and gene delivery applications. Especially the development of responsive LbL materials has advanced significantly in recent years. Responsiveness plays an important role in many delivery applications, either for loading of therapeutics or controlled and triggered release. In general four basic mechanisms within responsive LbL films have been identified: disruption of layer interactions, degradation of the LbL film, multilayer destruction via physical stimuli, and phase transitions or polymer rearrangements within the LbL film. This review will outline these different mechanisms and highlight recent advances in these fields. (c) 2011 Elsevier B.V. All rights reserved.

引用

页码：2 / 14

页数：13

共 178 条

[1] Polymeric Microcapsules Assembled from a Cationic/Zwitterionic Pair of Responsive Block Copolymer Micelles [J].

Addison, Timothy ;

Cayre, Olivier J. ;

Biggs, Simon ;

Armes, Steven P. ;

York, David .

LANGMUIR, 2010, 26 (09) :6281-6286

[2] Incorporation of Block Copolymer Micelles into Multilayer Films for Use as Nanodelivery Systems [J].

Addison, Timothy ;

Cayre, Olivier J. ;

Biggs, Simon ;

Armes, Steven P. ;

York, David .

LANGMUIR, 2008, 24 (23) :13328-13333

[3]

Antipina M.N., 2011, ADV DRUG DEL REV

[4] Polyelectrolyte multilayer capsule permeability control [J].

Antipov, AA ;

Sukhorukov, GB ;

Leporatti, S ;

Radtchenko, IL ;

Donath, E ;

Möhwald, H .

COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS, 2002, 198 :535-541

[5] Polyelectrolyte multilayer capsules as vehicles with tunable permeability [J].

Antipov, AA ;

Sukhorukov, GB .

ADVANCES IN COLLOID AND INTERFACE SCIENCE, 2004, 111 (1-2) :49-61

[6] Peptide Nucleic Acid Films and Capsules: Assembly and Enzymatic Degradation [J].

Becker, Alisa L. ;

Johnston, Angus P. R. ;

Caruso, Frank .

MACROMOLECULAR BIOSCIENCE, 2010, 10 (05) :488-495

[7] Tuning the Formation and Degradation of Layer-by-Layer Assembled Polymer Hydrogel Microcapsules [J].

Becker, Alisa L. ;

Zelikin, Alexander N. ;

Johnston, Angus P. R. ;

Caruso, Frank .

LANGMUIR, 2009, 25 (24) :14079-14085

[8] Optically driven encapsulation using novel polymeric hollow shells containing an azobenzene polymer [J].

Bedard, Matthieu ;

Skirtach, Andre G. ;

Sukhorukov, Gleb. B. .

MACROMOLECULAR RAPID COMMUNICATIONS, 2007, 28 (15) :1517-1521

[9] Polymeric microcapsules with light responsive properties for encapsulation and release [J].

Bedard, Matthieu F. ;

De Geest, Bruno G. ;

Skirtach, Andre G. ;

Moehwald, Helmuth ;

Sukhorukov, Gleb B. .

ADVANCES IN COLLOID AND INTERFACE SCIENCE, 2010, 158 (1-2) :2-14

[10] Layer-by-layer formation of smart particle coatings using oppositely charged block copolymer micelles [J].

Biggs, Simon ;

Sakai, Kenichi ;

Addison, Timothy ;

Schmid, Andreas ;

Armes, Steven P. ;

Vamvakaki, Maria ;

Butun, Vural ;

Webber, Grant .

ADVANCED MATERIALS, 2007, 19 (02) :247-+

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