Mediastinal lymph nodes staging by 18F-FDG PET/CT for early stage non-small cell lung cancer: A multicenter study

被引：48

作者：

Li, Xiaolin ^{[1
]}

Zhang, Huaqi ^{[1
]}

Xing, Ligang ^{[1
]}

Ma, Honglian ^{[2
]}

Xie, Peng ^{[1
]}

Zhang, Lin ^{[3
]}

Xu, Xiangying ^{[4
]}

Yue, Jinbo ^{[1
]}

Sun, Xindong ^{[1
]}

Hu, Xudong ^{[5
]}

Chen, Ming ^{[2
]}

Xu, Wengui ^{[6
]}

Chen, Lusheng ^{[5
]}

Yu, Jinming ^{[1
]}

机构：

[1] Shandong Tumor Hosp & Inst, Dept Radiat Oncol, Key Lab Radiat Oncol Shandong Prov, Jinan 250117, Shandong, Peoples R China

[2] Sun Yat Sen Univ, Ctr Canc, Dept Radiat Oncol, Guangzhou 510275, Guangdong, Peoples R China

[3] Shandong Univ, Prov Hosp, Dept Thorac Surg, Jinan 250100, Peoples R China

[4] Harbin Med Univ, Tumor Hosp, Dept Radiat Oncol, Harbin, Peoples R China

[5] Shandong Tumor Hosp & Inst, Dept Nucl Med, Jinan 250117, Shandong, Peoples R China

[6] Tianjin Med Univ, Canc Inst & Hosp, Dept Nucl Med, Tianjin, Peoples R China

来源：

RADIOTHERAPY AND ONCOLOGY | 2012年 / 102卷 / 02期

关键词：

F-18-FDG PET/CT; Stage I; NSCLC; Lymph node; SBRT; POSITRON-EMISSION-TOMOGRAPHY; STANDARDIZED UPTAKE VALUE; FDG-PET; STEREOTACTIC RADIOTHERAPY; MANAGEMENT; OUTCOMES; IMPACT;

D O I：

10.1016/j.radonc.2011.10.016

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Purpose: Accurate staging of mediastinal lymph nodes metastases is critical for determining the application of stereotactic body radiation therapy (SBRT) for patients with early stage non-small cell lung cancer (NSCLC). In this multicenter study the accuracy of F-18-FDG PET/CT to detect lymph node metastases was evaluated for early stage NSCLC. Materials and methods: The data from the patients with stage 1 NSCLC who received preoperative F-18-FDG PET/CT staging and radical surgery was retrospectively reviewed of five centers from February 2004 to August 2010. The lymph node metastases were confirmed histopathologically after radical surgery. And the sensitivity, specificity, accuracy, positive predictive value (PPV) and negative predictive value (NPV) were calculated for PET/CT staging. Results: Two hundred patients were enrolled. The sensitivity, specificity, accuracy. PPV and NPV for lymph node metastases on PET/CT were 44%, 83%, 78%, 29% and 91%, respectively. There were eight and 19 cases positive for lymph node metastases with central (n = 62) and peripheral (n = 138) NSCLC (P > 0.05), respectively. Conclusion: F-18-FDG PET/CT was specific in No staging for T1-2 NSCLC. The NPV was about 91% in clinical No patients, suggested that F-18-FDG PET/CT may help to accurately stage N-0 patients and thus identify patients for SBRT. Crown Copyright (C) 2011 Published by Elsevier Ireland Ltd. All rights reserved. Radiotherapy and Oncology 102 (2012) 246-250

引用

页码：246 / 250

页数：5

共 30 条

[11] 18F-FDG PET for mediastinal staging of lung cancer:: Which SUV threshold makes sense? [J].