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Yonsei Univ, Coll Med, Dept Internal Med,Brain Korea Project Med Sci 21, Div Gastroenterol,Inst Gastroenterol,Seodaemun Ku, Seoul, South Korea Yonsei Univ, Coll Med, Dept Internal Med,Brain Korea Project Med Sci 21, Div Gastroenterol,Inst Gastroenterol,Seodaemun Ku, Seoul, South Korea