Asymmetric total synthesis of (+)-fostriecin

被引：84

作者：

Reddy, YK ^{[1
]}

Falck, JR ^{[1
]}

机构：

[1] Univ Texas, SW Med Ctr, Dept Biochem, Dallas, TX 75390 USA

来源：

ORGANIC LETTERS | 2002年 / 4卷 / 06期

关键词：

D O I：

10.1021/ol025537r

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

[GRAPHICS] The title compound, a potent protein phosphatase inhibitor and anticancer agent, was prepared by an efficient, multiconvergent asymmetric synthesis. Key transformations include a ring forming olefin metathesis leading to the a-p-unsaturated lactone and creation of the triene moiety via Suzuki cross-coupling.

引用

页码：969 / 971

页数：3

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