Haemonchus contortus as a paradigm and model to study anthelmintic drug resistance

被引:111
作者
Gilleard, John S. [1 ]
机构
[1] Univ Calgary, Dept Comparat Biol & Expt Med, Fac Vet Med, Calgary, AB T2N 4Z6, Canada
关键词
Anthelmintic resistance; Haemonchus contortus; nematode; strongylid; genetics; genomics; Ivermectin; benzimidazoles; BENZIMIDAZOLE-RESISTANCE; CAENORHABDITIS-ELEGANS; RNA INTERFERENCE; TELADORSAGIA-CIRCUMCINCTA; AVERMECTIN RESISTANCE; GENETIC-VARIABILITY; POSITIVE SELECTION; COMPLEX TRAITS; POPULATIONS; IVERMECTIN;
D O I
10.1017/S0031182013001145
中图分类号
R38 [医学寄生虫学]; Q [生物科学];
学科分类号
07 ; 0710 ; 09 ; 100103 ;
摘要
Anthelmintic resistance is a major problem for the control livestock parasites and a potential threat to the sustainability of community-wide treatment programmes being used to control human parasites in the developing world. Anthelmintic resistance is essentially a complex quantitative trait in which multiple mutations contribute to the resistance phenotype in an additive manner. Consequently, a combination of forward genetic and genomic approaches are needed to identify the causal mutations and quantify their contribution to the resistance phenotype. Therefore, there is a need to develop genetic and genomic approaches for key parasite species identified as relevant models. Haemonchus contortus, a gastro-intestinal parasite of sheep, has shown a remarkable propensity to develop resistance to all the drugs used in its control. Partly because of this, and partly because of its experimental amenability, research on this parasite has contributed more than any other to our understanding of anthelmintic resistance. H. contortus offers a variety of advantages as an experimental system including the ability to undertake genetic crosses; a prerequisite for genetic mapping. This review will discuss the current progress on developing H. contortus as a model system in which to study anthelmintic resistance.
引用
收藏
页码:1506 / 1522
页数:17
相关论文
共 86 条
[1]  
Anderson T, 2011, PHARMACOGENOMICS, V12, P59, DOI [10.2217/pgs.10.165, 10.2217/PGS.10.165]
[2]  
[Anonymous], 2000, NEMATODE PARASITES V
[3]   Relationship between increased albendazole systemic exposure and changes in single nucleotide polymorphisms on the β-tubulin isotype 1 encoding gene in Haemonchus contortus [J].
Barrere, Virginie ;
Alvarez, Luis ;
Suarez, Gonzalo ;
Ceballos, Laura ;
Moreno, Laura ;
Lanusse, Carlos ;
Prichard, Roger K. .
VETERINARY PARASITOLOGY, 2012, 186 (3-4) :344-349
[4]   Anthelmintic resistance: markers for resistance, or susceptibility? [J].
Beech, R. N. ;
Skuce, P. ;
Bartley, D. J. ;
Martin, R. J. ;
Prichard, R. K. ;
Gilleard, J. S. .
PARASITOLOGY, 2011, 138 (02) :160-174
[5]   Selection at a P-glycoprotein gene in ivermectin- and moxidectin-selected strains of Haemonchus contortus [J].
Blackhall, WJ ;
Liu, HY ;
Xu, M ;
Prichard, RK ;
Beech, RN .
MOLECULAR AND BIOCHEMICAL PARASITOLOGY, 1998, 95 (02) :193-201
[6]   A molecular evolutionary framework for the phylum Nematoda [J].
Blaxter, ML ;
De Ley, P ;
Garey, JR ;
Liu, LX ;
Scheldeman, P ;
Vierstraete, A ;
Vanfleteren, JR ;
Mackey, LY ;
Dorris, M ;
Frisse, LM ;
Vida, JT ;
Thomas, WK .
NATURE, 1998, 392 (6671) :71-75
[7]  
BLOUIN MS, 1995, GENETICS, V141, P1007
[8]   Genomewide Scan Reveals Amplification of mdr1 as a Common Denominator of Resistance to Mefloquine, Lumefantrine, and Artemisinin in Plasmodium chabaudi Malaria Parasites [J].
Borges, Sofia ;
Cravo, Pedro ;
Creasey, Alison ;
Fawcett, Richard ;
Modrzynska, Katarzyna ;
Rodrigues, Louise ;
Martinelli, Axel ;
Hunt, Paul .
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2011, 55 (10) :4858-4865
[9]   Host isolation and patterns of genetic variability in three populations of Teladorsagia from sheep [J].
Braisher, TL ;
Gemmell, NJ ;
Grenfell, BT ;
Amos, W .
INTERNATIONAL JOURNAL FOR PARASITOLOGY, 2004, 34 (10) :1197-1204
[10]   The detection of anthelmintic resistance in nematodes of veterinary importance [J].
Coles, GC ;
Jackson, F ;
Pomroy, WE ;
Prichard, RK ;
von Samson-Himmelstjerna, G ;
Silvestre, A ;
Taylor, MA ;
Vercruysse, J .
VETERINARY PARASITOLOGY, 2006, 136 (3-4) :167-185