Histopathological and immunohistochemical aspects of mastocytosis

被引:54
作者
Horny, HP
Valent, P
机构
[1] Med Univ Lubeck, Inst Pathol, D-23538 Lubeck, Germany
[2] Univ Vienna, Dept Internal Med, Div Hematol & Hemostaseol, Vienna, Austria
关键词
mast cell; mastocytosis; immunohistochemistry; tryptase;
D O I
10.1159/000048180
中图分类号
R392 [医学免疫学];
学科分类号
100102 ;
摘要
The diagnosis of mastocytosis is based on histological evidence of a focal increase in tissue mast cells. Immunohistochemical staining with antitryptase antibodies is strongly recommended in all cases of suspected mastocytosis because mast cell infiltrates may be small and scanty. Mastocytosis may be difficult to distinguish from other hematological malignancies, in which an increase in mast cells is frequently seen. The expression of the T cell-associated antigen CD2 has been shown to be exclusively found on neoplastic mast cells in mastocytosis. The demonstration of expression of vascular endothelial growth factor by mast cells is consistent with the finding of angiogenesis which is commonly seen in tissue infiltrates of mastocytosis. Copyright (C) 2002 S. KargerAG, Basel.
引用
收藏
页码:115 / 117
页数:3
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