A MILD AND CONVENIENT ONE-POT SYNTHESIS OF 4-ARYL-N-OH-HANTZSCH ESTERS

被引：3
作者：
Miao, Chun-Bao [1 ]
Dong, Chun-Ping [1 ]
Wang, Yan-Hong [1 ]
Yang, Hai-Tao [1 ]
Meng, Qi [1 ]
Tu, Shu-Jiang [2 ]
Sun, Xiao-Qiang [1 ]
机构：
[1] Changzhou Univ, Sch Petrochem Engn, Changzhou 213164, Peoples R China
[2] Jiangsu Normal Univ, Sch Chem & Chem Engn, Xuzhou 221116, Peoples R China
来源：
HETEROCYCLES | 2013年 / 87卷 / 04期
基金：
中国国家自然科学基金;
关键词：
1,4-Dihydropyridine; Michael Addition; One-Pot Reaction; Hydroxylamine; N-OH-Hantzsch Ester; BIOLOGICAL EVALUATION; DIMERIC 4-ARYL-1,4-DIHYDROPYRIDINES; 1,4-DIHYDROPYRIDINE SCAFFOLD; DIHYDROPYRIDINE DERIVATIVES; ANTIINFLAMMATORY AGENTS; AMIDE DERIVATIVES; CALCIUM-CHANNELS; IN-VITRO; ACID; CHEMISTRY;
D O I：
10.3987/COM-13-12668
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A general methodology to prepare a series of 4-Aryl-N-OH Hantzsch esters was developed. The key factor is to control the first-step of Michael addition at 0 degrees C. The method was practical to produce symmetrical and unsymmetric N-OH-Hantzsch esters in moderate yield. This class of compounds might have use in medicinal and material science.
引用
收藏
页码：853 / +
页数：8
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