A MILD AND CONVENIENT ONE-POT SYNTHESIS OF 4-ARYL-N-OH-HANTZSCH ESTERS

被引：3
作者：
Miao, Chun-Bao [1 ]
Dong, Chun-Ping [1 ]
Wang, Yan-Hong [1 ]
Yang, Hai-Tao [1 ]
Meng, Qi [1 ]
Tu, Shu-Jiang [2 ]
Sun, Xiao-Qiang [1 ]
机构：
[1] Changzhou Univ, Sch Petrochem Engn, Changzhou 213164, Peoples R China
[2] Jiangsu Normal Univ, Sch Chem & Chem Engn, Xuzhou 221116, Peoples R China
来源：
HETEROCYCLES | 2013年 / 87卷 / 04期
基金：
中国国家自然科学基金;
关键词：
1,4-Dihydropyridine; Michael Addition; One-Pot Reaction; Hydroxylamine; N-OH-Hantzsch Ester; BIOLOGICAL EVALUATION; DIMERIC 4-ARYL-1,4-DIHYDROPYRIDINES; 1,4-DIHYDROPYRIDINE SCAFFOLD; DIHYDROPYRIDINE DERIVATIVES; ANTIINFLAMMATORY AGENTS; AMIDE DERIVATIVES; CALCIUM-CHANNELS; IN-VITRO; ACID; CHEMISTRY;
D O I：
10.3987/COM-13-12668
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A general methodology to prepare a series of 4-Aryl-N-OH Hantzsch esters was developed. The key factor is to control the first-step of Michael addition at 0 degrees C. The method was practical to produce symmetrical and unsymmetric N-OH-Hantzsch esters in moderate yield. This class of compounds might have use in medicinal and material science.
引用
收藏
页码：853 / +
页数：8
相关论文
共 50 条
  • [31] Convenient one-pot synthesis and biological evaluation of phosphoramidates and phosphonates containing heterocycles
    Rasool, S. K. Nayab
    Subramanyam, Ch.
    Janakiramudu, D. B.
    Supraja, P.
    Usha, R.
    Raju, C. Naga
    PHOSPHORUS SULFUR AND SILICON AND THE RELATED ELEMENTS, 2018, 193 (07) : 470 - 474
  • [32] Efficient and Convenient Synthesis of N3-(Acyloxymethyl)dihydropyrimidinones by a One-Pot Two-Step Method
    Quan, Zheng-Jun
    Ren, Rong-Guo
    Da, Yu-Xia
    Zhang, Zhang
    Wang, Xi-Cun
    LETTERS IN ORGANIC CHEMISTRY, 2011, 8 (03) : 188 - 192
  • [33] One-Pot Synthesis of 2-(Alkylsulfanyl)quinolines from Aryl Isothiocyanates and Allenes or Alkynes
    Nedolya, Nina A.
    Tarasova, Ol'ga A.
    Artem'ev, Alexander V.
    Albanov, Alexander I.
    Bagryanskaya, Irina Yu.
    Trofimov, Boris A.
    EUROPEAN JOURNAL OF ORGANIC CHEMISTRY, 2024, 27 (13)
  • [34] A Convenient and Facile Hantzsch Synthesis of Aryl Imidazo [1,2-b]Isoxazolyl-N-aryl Thiazol Amines
    Rajanarendar, E.
    Thirupathaiah, K.
    Ramakrishna, S.
    Nagaraju, D.
    JOURNAL OF HETEROCYCLIC CHEMISTRY, 2016, 53 (06) : 1983 - 1989
  • [35] Ultrasound-assisted one-pot, four component synthesis of 4-aryl 3,4-dihydropyridone derivatives
    Ruiz, Enrique
    Rodriguez, Hortensia
    Coro, Julieta
    Salfran, Esperanza
    Suarez, Margarita
    Martinez-Alvarez, Roberto
    Martin, Nazario
    ULTRASONICS SONOCHEMISTRY, 2011, 18 (01) : 32 - 36
  • [36] Aluminum phosphate [AlPO4(H)]: A mild and efficient recyclable catalyst for one-pot synthesis of polyhydroquinoline via the Hantzsch reaction under solvent-free conditions
    Purandhar, K.
    Jyothi, V.
    Reddy, P. Pratap
    Chari, M. Adharvana
    Mukkanti, K.
    JOURNAL OF HETEROCYCLIC CHEMISTRY, 2012, 49 (01) : 232 - 236
  • [37] One-Pot Synthesis of β-Keto Esters and Preparation of 3-Ketopalmitoyl-CoA
    Kosak, Urban
    Kovac, Andreja
    Gobec, Stanislav
    SYNLETT, 2012, (11) : 1609 - 1612
  • [38] An efficient and convenient one-pot multicomponent synthesis of novel pyrimidine derivatives: N-(4-aryl-6-(pyridin-2-yl)pyrimidin-2-yl)cyanamides
    Rong, Liangce
    Wei, Xianyong
    Tao, Shimin
    Lu, Yao
    Xie, Ruilun
    Zhou, Jun
    Zong, Zhimin
    RESEARCH ON CHEMICAL INTERMEDIATES, 2013, 39 (04) : 1907 - 1916
  • [39] "One-Pot" Chemo-enzymatic Synthesis of Chiral α-Halogenated Aryl Alcohols
    Yang, Jingwen
    Chen, Jianbo
    Wang, Shijie
    Wu, Xiaomei
    Ma, Baodi
    Xu, Yi
    CHINESE JOURNAL OF ORGANIC CHEMISTRY, 2018, 38 (07) : 1811 - 1816
  • [40] Regioselective cycloaddition of acetylenic esters: a one-pot synthesis of novel dihydrobenzo[a]carbazoles
    Yamuna, Ezhumalai
    Zeller, Matthias
    Prasad, Karnam Jayarampillai Rajendra
    TETRAHEDRON LETTERS, 2011, 52 (14) : 1649 - 1652
12345