A MILD AND CONVENIENT ONE-POT SYNTHESIS OF 4-ARYL-N-OH-HANTZSCH ESTERS

被引：3

作者：

Miao, Chun-Bao ^{[1
]}

Dong, Chun-Ping ^{[1
]}

Wang, Yan-Hong ^{[1
]}

Yang, Hai-Tao ^{[1
]}

Meng, Qi ^{[1
]}

Tu, Shu-Jiang ^{[2
]}

Sun, Xiao-Qiang ^{[1
]}

机构：

[1] Changzhou Univ, Sch Petrochem Engn, Changzhou 213164, Peoples R China

[2] Jiangsu Normal Univ, Sch Chem & Chem Engn, Xuzhou 221116, Peoples R China

来源：

HETEROCYCLES | 2013年 / 87卷 / 04期

基金：

中国国家自然科学基金;

关键词：

1,4-Dihydropyridine; Michael Addition; One-Pot Reaction; Hydroxylamine; N-OH-Hantzsch Ester; BIOLOGICAL EVALUATION; DIMERIC 4-ARYL-1,4-DIHYDROPYRIDINES; 1,4-DIHYDROPYRIDINE SCAFFOLD; DIHYDROPYRIDINE DERIVATIVES; ANTIINFLAMMATORY AGENTS; AMIDE DERIVATIVES; CALCIUM-CHANNELS; IN-VITRO; ACID; CHEMISTRY;

D O I：

10.3987/COM-13-12668

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A general methodology to prepare a series of 4-Aryl-N-OH Hantzsch esters was developed. The key factor is to control the first-step of Michael addition at 0 degrees C. The method was practical to produce symmetrical and unsymmetric N-OH-Hantzsch esters in moderate yield. This class of compounds might have use in medicinal and material science.

引用

页码：853 / +

页数：8

共 50 条

[21] One-Pot Synthesis of Aryl Selenonic Acids and Some Unexpected Byproducts
Sands, Kai N.
Gelfand, Benjamin S.
Back, Thomas G.
JOURNAL OF ORGANIC CHEMISTRY, 2021, 86 (15) : 9938 - 9944
[22] AMINE-MEDIATED SEQUENTIAL ONE-POT SYNTHESIS OF HIGHLY SUBSTITUTED THIOPHENES FROM β-KETO ESTERS, ARYL ISOTHIOCYANATES AND 4-CHLOROACETOACETATE
Alizadeh, Abdolali
Hosseinabadi, Marzieh
Bayat, Fahimeh
PHOSPHORUS SULFUR AND SILICON AND THE RELATED ELEMENTS, 2015, 190 (07) : 1056 - 1063
[23] One-Pot Synthesis of N-Furanonyl Sulfonyl Hydrazone Compounds
Chen, Renhong
Wu, Guizhen
Yang, Kai
Ye, Bin
Chen, Qingfeng
Wang, Zhaoyang
CHINESE JOURNAL OF ORGANIC CHEMISTRY, 2021, 41 (07) : 2750 - 2759
[24] Ceria-Molybdenum Mix Metal Oxide: A Mild and Efficient Recyclable Catalyst for One-Pot Synthesis of Polyhydroquinoline via Hantzsch Reaction
Bansode, Nilam D.
Gadekar, Sachin P.
Gaikwad, Suresh T.
Lande, Machhindra K.
ORBITAL-THE ELECTRONIC JOURNAL OF CHEMISTRY, 2020, 12 (01): : 17 - 23
[25] One-Pot Synthesis of Dicarbazolyl(aryl)methanols Based on α-Keto Acids
Cai, Jun-Xian
Chen, Peng
Li, Jian-Ye
Du, Hongying
Jiang, Yi-Jun
SYNLETT, 2025, 36 (06) : 744 - 748
[26] A catalytic and green method for one-pot synthesis of new Hantzsch 1,4-dihydropyridines
Jassem, Ahmed Majeed
Almashal, Faeza Abdul Kareem
Mohammed, Mohammed Qasim
Jabir, Hadi Abdal Samad
SN APPLIED SCIENCES, 2020, 2 (03):
[27] Convenient one-pot synthesis of monofluorinated functionalized 4-H-pyran derivatives via multi-component reactions
Xu, Xiaoling
Shi, Wei
Zhou, Yu
Wang, Yang
Zhang, Min
Song, Liping
Deng, Hongmei
JOURNAL OF FLUORINE CHEMISTRY, 2015, 176 : 127 - 133
[28] A CONVENIENT ONE-POT SYNTHESIS OF ARENE-CENTERED TRIS(THIAZOLINE) COMPOUNDS
Lu, Xuhong
Qi, Qingqing
Mao, Yumei
Li, Nan
Fu, Bin
HETEROCYCLES, 2009, 78 (04) : 1031 - 1039
[29] A One-Pot Synthesis of trans-N-Alkylaziridine-2-carboxylates from Amino Alcohol Esters
Kaabi, Amani
Elemine, Brahim Ould
Besbes, Rafaa
SYNTHETIC COMMUNICATIONS, 2011, 41 (10) : 1472 - 1480
[30] One-pot synthesis of N-aryl 1,4-dihydropyridine derivatives and their biological activities
Dhinakaran, Isaivani
Padmini, Vediappen
Bhuvanesh, Nattamai
JOURNAL OF CHEMICAL SCIENCES, 2015, 127 (12) : 2201 - 2209

← 1 2 3 4 5 →