A MILD AND CONVENIENT ONE-POT SYNTHESIS OF 4-ARYL-N-OH-HANTZSCH ESTERS

被引：3
|
作者：
Miao, Chun-Bao [1 ]
Dong, Chun-Ping [1 ]
Wang, Yan-Hong [1 ]
Yang, Hai-Tao [1 ]
Meng, Qi [1 ]
Tu, Shu-Jiang [2 ]
Sun, Xiao-Qiang [1 ]
机构：
[1] Changzhou Univ, Sch Petrochem Engn, Changzhou 213164, Peoples R China
[2] Jiangsu Normal Univ, Sch Chem & Chem Engn, Xuzhou 221116, Peoples R China
来源：
HETEROCYCLES | 2013年 / 87卷 / 04期
基金：
中国国家自然科学基金;
关键词：
1,4-Dihydropyridine; Michael Addition; One-Pot Reaction; Hydroxylamine; N-OH-Hantzsch Ester; BIOLOGICAL EVALUATION; DIMERIC 4-ARYL-1,4-DIHYDROPYRIDINES; 1,4-DIHYDROPYRIDINE SCAFFOLD; DIHYDROPYRIDINE DERIVATIVES; ANTIINFLAMMATORY AGENTS; AMIDE DERIVATIVES; CALCIUM-CHANNELS; IN-VITRO; ACID; CHEMISTRY;
D O I：
10.3987/COM-13-12668
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A general methodology to prepare a series of 4-Aryl-N-OH Hantzsch esters was developed. The key factor is to control the first-step of Michael addition at 0 degrees C. The method was practical to produce symmetrical and unsymmetric N-OH-Hantzsch esters in moderate yield. This class of compounds might have use in medicinal and material science.
引用
收藏
页码：853 / +
页数：8
相关论文
共 50 条
  • [1] A mild, chemoselective, one-pot synthesis of δ-keto α-cyano esters by organocatalysis
    Liu, Gang
    Wang, Yingcai
    TETRAHEDRON LETTERS, 2014, 55 (01) : 189 - 192
  • [2] Mild and convenient one-pot synthesis of 1,3,4-oxadiazoles
    Stabile, Paolo
    Lamonica, Alessandro
    Ribecai, Arianna
    Castoldi, Damiano
    Guercio, Giuseppe
    Curcuruto, Ornella
    TETRAHEDRON LETTERS, 2010, 51 (37) : 4801 - 4805
  • [3] A convenient one-pot synthesis of aryl amines from aryl aldoximes mediated by Koser's reagent
    Ghosh, Harisadhan
    Baneerjee, Arghya
    Rout, Saroj Kumar
    Patel, Bhisma K.
    ARKIVOC, 2011, : 209 - 216
  • [4] Convenient one-pot multicomponent strategy for the synthesis of 6-pyrrolylpyrimidines
    Dhanalakshmi, Pandi
    Shanmugam, Sivakumar
    RSC ADVANCES, 2014, 4 (56) : 29493 - 29501
  • [5] LiBr as an Efficient Catalyst for One-pot Synthesis of Hantzsch 1,4-Dihydropyridines under Mild Conditions
    Yadav, D. K.
    Patel, R.
    Srivastava, V. P.
    Watal, G.
    Yadav, L. D. S.
    CHINESE JOURNAL OF CHEMISTRY, 2011, 29 (01) : 118 - 122
  • [6] A convenient synthesis of functionalized trifluoromethylated 2-((isoxazolyl)(aryl)methyl)malononitrile derivatives via one-pot MCRs
    Zhang, Yiping
    Zhou, Yingkai
    Zhang, Min
    Song, Liping
    TETRAHEDRON LETTERS, 2023, 123
  • [7] One-Pot Synthesis of O-Aryl Carbamates
    Varjosaari, Sami E.
    Suating, Paolo
    Adler, Marc J.
    SYNTHESIS-STUTTGART, 2016, 48 (01): : 43 - 47
  • [8] A MILD AND CONVENIENT ONE-POT SYNTHESIS OF 4,6-DIARYL3-AMINOISOXAZOLO[3,4-b]PYRIDINES
    Miao, Chun-Bao
    Wang, Yan-Hong
    Dong, Chun-Ping
    Yang, Hai-Tao
    Meng, Qi
    Sun, Xiao-Qiang
    HETEROCYCLES, 2013, 87 (12) : 2599 - 2605
  • [9] A convenient one-pot synthesis of phosphino-dipeptide analogs
    Pirat, JL
    Coulombeau, A
    Genevois-Borella, A
    Cristau, HJ
    PHOSPHORUS SULFUR AND SILICON AND THE RELATED ELEMENTS, 2002, 177 (6-7) : 1793 - 1796
  • [10] A convenient one-pot synthesis of phosphino-dipeptide analogs
    Cristau, HJ
    Coulombeau, A
    Genevois-Borella, A
    Pirat, JL
    TETRAHEDRON LETTERS, 2001, 42 (27) : 4491 - 4494
12345