Activation and regulation of the inflammasomes

被引：2372

作者：

Latz, Eicke ^{[1
,2
,3
,4
,5
]}

Xiao, T. Sam ^{[6
]}

Stutz, Andrea ^{[1
]}

机构：

[1] Univ Bonn, Univ Hosp, Inst Innate Immun, D-53127 Bonn, Germany

[2] Univ Massachusetts, Sch Med, Dept Med, Worcester, MA 01655 USA

[3] Univ Massachusetts, Sch Med, Div Infect Dis & Immunol, Worcester, MA 01655 USA

[4] DZNE, D-53175 Bonn, Germany

[5] Norwegian Univ Sci & Technol, Ctr Mol Inflammat Res, NO-7491 Trondheim, Norway

[6] NIAID, Struct Immunobiol Unit, Immunol Lab, NIH, Bethesda, MD 20892 USA

来源：

NATURE REVIEWS IMMUNOLOGY | 2013年 / 13卷 / 06期

基金：

美国国家卫生研究院;

关键词：

NF-KAPPA-B; NOD-LIKE RECEPTOR; NLRP3; INFLAMMASOME; NALP3; CYTOCHROME-C; INTERLEUKIN-1-BETA RELEASE; CASPASE-1; ACTIVATION; IL-1-BETA PRODUCTION; ADAPTIVE IMMUNITY; AIM2;

D O I：

10.1038/nri3452

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Inflammasomes are key signalling platforms that detect pathogenic microorganisms and sterile stressors, and that activate the highly pro-inflammatory cytokines interleukin-1 beta (IL-1 beta) and IL-18. In this Review, we discuss the complex regulatory mechanisms that facilitate a balanced but effective inflammasome-mediated immune response, and we highlight the similarities to another molecular signalling platform - the apoptosome - that monitors cellular health. Extracellular regulatory mechanisms are discussed, as well as the intracellular control of inflammasome assembly, for example, via ion fluxes, free radicals and autophagy.

引用

页码：397 / 411

页数：15

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