Protein corona significantly reduces active targeting yield

被引：308

作者：

Mirshafiee, Vahid ^{[1
]}

Mahmoudi, Morteza ^{[2
,3
,4
]}

Lou, Kaiyan ^{[1
]}

Cheng, Jianjun ^{[5
]}

Kraft, Mary L. ^{[1
,2
]}

机构：

[1] Univ Illinois, Dept Chem & Biomol Engn, Urbana, IL 61801 USA

[2] Univ Illinois, Dept Chem, Urbana, IL 61801 USA

[3] Univ Tehran Med Sci, Dept Nanotechnol, Tehran, Iran

[4] Univ Tehran Med Sci, Nanotechnol Res Ctr, Fac Pharmaceut, Tehran, Iran

[5] Univ Illinois, Dept Mat Sci & Engn, Urbana, IL 61801 USA

来源：

CHEMICAL COMMUNICATIONS | 2013年 / 49卷 / 25期

关键词：

GOLD NANOPARTICLES; MECHANISM; SIZE;

D O I：

10.1039/c3cc37307j

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

When nanoparticles (NPs) are exposed to the biological environment, their surfaces become covered with proteins and biomolecules (e. g. lipids). Here, we report that this protein coating, or corona, reduces the targeting capability of surface engineered NPs by screening the active sites of the targeting ligands.

引用

页码：2557 / 2559

页数：3

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