Therapeutic application of nutraceuticals in diabetic nephropathy: Current evidence and future implications

被引：28
作者：
Dehdashtian, Ehsan [1 ]
Pourhanifeh, Mohammad Hossein [2 ]
Hemati, Karim [3 ]
Mehrzadi, Saeed [4 ]
Hosseinzadeh, Azam [4 ]
机构：
[1] Iran Univ Med Sci, Sch Med, Tehran, Iran
[2] Kashan Univ Med Sci, Res Ctr Biochem & Nutr Metab Dis, Kashan, Iran
[3] Iran Univ Med Sci, Dept Anesthesiol, Tehran, Iran
[4] Iran Univ Med Sci, Razi Drug Res Ctr, Tehran, Iran
来源：
DIABETES-METABOLISM RESEARCH AND REVIEWS | 2020年 / 36卷 / 08期
关键词：
berberine; curcumin; diabetes mellitus; diabetic nephropathy; dietary supplementation; melatonin; natural products; Nutraceuticals; polyphenol; quercetin; resveratrol; NF-KAPPA-B; INTERCELLULAR-ADHESION MOLECULE-1; HIGH-FAT DIET; INDUCED INFLAMMATORY RESPONSE; MESANGIAL CELL-PROLIFERATION; ACTIVATED PROTEIN-KINASE; AMELIORATES RENAL INJURY; OXIDATIVE STRESS; SIGNALING PATHWAY; IN-VITRO;
D O I：
10.1002/dmrr.3336
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Diabetes mellitus (DM) is a common metabolic disease which may cause several complications, such as diabetic nephropathy (DN). The routine medical treatments used for DM are not effective enough and have many undesirable side effects. Moreover, the global increased prevalence of DM makes researchers try to explore potential complementary or alternative treatments. Nutraceuticals, as natural products with pharmaceutical agents, have a wide range of therapeutic properties in various pathologic conditions such as DN. However, the exact underlying mechanisms have not been fully understood. The purpose of this review is to summarize recent findings on the effect of nutraceuticals on DN.
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页数：21
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