Systhesis of enantiopure aminocyclopropanes by diastereoselective addition of chiral amino substituted organozinc carbenoid to alkenes

被引：23
作者：
Bégis, G
Sheppard, TD
Cladingboel, DE
Motherwell, WB
Tocher, DA
机构：
[1] UCL, Dept Chem, Christopher Ingold Labs, London WC1H 0AJ, England
[2] AstraZeneca R&D Charnwood, Loughborough LE11 5RH, Leics, England
来源：
SYNTHESIS-STUTTGART | 2005年 / 19期
关键词：
alkenes; carbenoids; chiral auxiliaries; electrophilic addition; zinc;
D O I：
10.1055/s-2005-918469
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
The synthesis of enantiopure aminocyclopropanes is reported, via direct aminocyclopropanation of alkenes with a zinc carbenoid containing a chiral auxiliary. The methodology was applied to the synthesis of a protected aminocyclopropane present in the immunosuppressant Belactosin A.
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收藏
页码：3186 / 3188
页数：3
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