Meditation's impact on default mode network and hippocampus in mild cognitive impairment: A pilot study

被引：126

作者：

Wells, Rebecca Erwin ^{[1
]}

Yeh, Gloria Y. ^{[1
]}

Kerr, Catherine E. ^{[2
]}

Wolkin, Jennifer ^{[1
]}

Davis, Roger B. ^{[1
]}

Tan, Ying ^{[3
]}

Spaeth, Rosa ^{[3
]}

Wall, Robert B. ^{[4
]}

Walsh, Jacquelyn ^{[5
]}

Kaptchuk, Ted J. ^{[1
]}

Press, Daniel ^{[1
]}

Phillips, Russell S. ^{[1
]}

Kong, Jian ^{[3
]}

机构：

[1] Harvard Univ, Sch Med, BIDMC, Boston, MA 02215 USA

[2] Brown Univ, Sch Med, Providence, RI 02912 USA

[3] Massachusetts Gen Hosp, Charlestown, MA 02129 USA

[4] Commonwealth Care Alliance, Boston, MA 02108 USA

[5] Brigham & Womens Hosp, Boston, MA 02215 USA

来源：

NEUROSCIENCE LETTERS | 2013年 / 556卷

基金：

美国国家卫生研究院;

关键词：

Mild cognitive impairment; Alzheimer's Disease; fMRI; Meditation; Default mode network; Hippocampus; FUNCTIONAL CONNECTIVITY; MINDFULNESS MEDITATION; ALZHEIMERS-DISEASE; MECHANISMS; EXPERIENCE; INCREASES; EXERCISE; DISTRESS; PAIN;

D O I：

10.1016/j.neulet.2013.10.001

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Those with high baseline stress levels are more likely to develop mild cognitive impairment (MCI) and Alzheimer's Disease (AD). While meditation may reduce stress and alter the hippocampus and default mode network (DMN), little is known about its impact in these populations. Our objective was to conduct a "proof of concept" trial to determine whether Mindfulness Based Stress Reduction (MBSR) would improve DMN connectivity and reduce hippocampal atrophy among adults with MCI. 14 adults with MCI were randomized to MBSR vs. usual care and underwent resting state fMRI at baseline and follow-up. Seed based functional connectivity was applied using posterior cingulate cortex as seed. Brain morphometry analyses were performed using FreeSurfer. The results showed that after the intervention, MBSR participants had increased functional connectivity between the posterior cingulate cortex and bilateral medial prefrontal cortex and left hippocampus compared to controls. In addition, MBSR participants had trends of less bilateral hippocampal volume atrophy than control participants. These preliminary results indicate that in adults with MCI, MBSR may have a positive impact on the regions of the brain most related to MCI and AD. Further research with larger sample sizes and longer-follow-up are needed to further investigate the results from this pilot study. (C) 2013 Elsevier Ireland Ltd. All rights reserved.

引用

页码：15 / 19

页数：5

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